{"doi":"10.3389/fmed.2022.1026202","title":"Editorial: Molecular mechanisms of proteinuria, volume II","abstract":"Proteinuria, which is defined as persistent and increased leakage of protein in the urine, is a consequence of an altered glomerular filtration and is considered a key marker for renal barrier dysfunction. In support, the recent recognition of the predictive link between proteinuria and disease progression to organ failure in kidney diseases has led to recommend proteinuria as an approvable primary endpoint by regulatory organizations, which will allow for the increased evaluation of investigational therapies in patients with kidney disease and accelerate the drug discovery process (1, 2). However, the molecular mechanisms leading to the development of proteinuria are complex, and there is a need to decipher these for a new generation of therapeutic drugs to treat the millions of people suffering from kidney disease.","journal":"Frontiers in Medicine","year":2022,"id":312324,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":312515,"name":"Sandra Merscher","orcid":"0000-0002-4757-7494","position":1,"is_corresponding":false},{"id":284302,"name":"Ilse S. Daehn","orcid":"0000-0001-9915-5376","position":0,"is_corresponding":true}],"reference_count":5,"raw_metadata":null,"created_at":"2026-07-19T00:33:36.072096Z","pmid":"36313992","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}