{"doi":"10.3389/fimmu.2024.1504432","title":"Editorial: The synthesis of secretory immunoglobulin A in mucosal tissue: mucosal-associated invariant T, T follicular helper, and B cells","abstract":"and regulation within the respiratory mucosa. The authors offered a comprehensive overview of the anatomy of the upper and lower respiratory tracts, along with their associated lymphoid tissues, emphasizing the critical role of IgA in mucosal immunity within these regions. Additionally, they explored preclinical mucosal vaccine approaches currently under development and discussed potential strategies for targeting the respiratory tract to induce immune tolerance. The review highlights how a deeper understanding of nasal-associated lymphoid tissue (NALT) and bronchial-associated lymphoid tissue (BALT) biology can inform the development of more effective strategies for immune activation and tolerance modulation. This review is particularly timely, not only in light of the recent pandemics caused by the 2009 influenza A (H1N1) 11 and 2019 SARS-CoV-2 12 viruses, but also due to the ongoing global battle against respiratory diseases such as tuberculosis and influenza.A timely review by Carreto-Binaghi et al. offers a fresh perspective on IgA's role in the intestinal mucosa. The authors emphasize IgA's critical function in maintaining homeostasis and protecting against enteric bacterial pathogens. They not only highlight the interplay between MAIT, TFH, and B cells in IgA production, but also explore the contributions of other cell subsets, such as regulatory T cells (Tregs), innate lymphoid cells (ILCs), dendritic cells (DCs), macrophages (MΦ), eosinophils, and epithelial cells. These cells contribute directly or indirectly to IgA production, forming a complex, coordinated immune network essential for maintaining mucosal homeostasis. The review also discusses the role of long-lived memory B cells and antibody-secreting cells in sustaining IgA production, as well as how vaccination and infection influence the long-term maintenance of pre-existing IgA. Understanding the impact of these long-lived cells is essential for developing effective oral vaccines. Additionally, insights into how prior infections or vaccinations affect the long-term presence of IgA can help guide the design of vaccines that leverage pre-existing immunity to strengthen protective responses at mucosal surfaces.MAIT cells are conventionally known for their anti-infective activities against bacteria and viruses. This review by Gao et al. explores recent discoveries regarding additional functions of MAIT cells, including their roles in maintaining and repairing local tissues, such as the intestinal mucosa, meningeal barrier, and skin. The authors provided a systematic review of their phenotypes and targeted their chemotaxis in context to their local tissue residence, maintenance, and immunoregulatory role in wound healing. Furthermore, the authors included a perspective on the future implementation of the homeostatic functions of MAIT cells in developing therapies for chronic inflammation and/or restoring tissue integrity. There are potential challenges to overcome, particularly in obtaining human mucosal tissues and developing ex vivo research models that accurately simulate in vivo disease environments, among others. It is worth highlighting that intranasal co-administration of protein antigens with a strong MAIT cell ligand stimulates mucosal IgA production, positioning MAIT cells as a potential cellular adjuvant for enhancing humoral immunity for vaccine development 13 .We believe that this Research Topic offers an updated perspective on the contribution of MAIT, TFH, and B cells to the production of IgA and the development of advanced vaccines and targeted intervention strategies.","journal":"Frontiers in Immunology","year":2024,"id":492151,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9638,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":528543,"name":"Rezwanul Wahid","orcid":"0000-0002-5623-1903","position":1,"is_corresponding":false},{"id":1338426,"name":"Dunja Bruder","orcid":null,"position":2,"is_corresponding":false},{"id":420602,"name":"Rosângela Salerno-Gonçalves","orcid":"0000-0003-2999-4275","position":3,"is_corresponding":false},{"id":503767,"name":"Jayaum S. Booth","orcid":null,"position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:08:49.768795Z","pmid":"39483477","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}