{"doi":"10.3389/fimmu.2024.1446730","title":"Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers","abstract":"Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.","journal":"Frontiers in Immunology","year":2024,"id":445416,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344428,"name":"Wendy Fitzgerald","orcid":"0000-0001-5752-8250","position":1,"is_corresponding":false},{"id":1261826,"name":"Jacobo Alonso-Domínguez","orcid":null,"position":2,"is_corresponding":false},{"id":1261342,"name":"José Aguayo-Arjona","orcid":"0009-0002-3036-7391","position":3,"is_corresponding":false},{"id":400476,"name":"Ana Mariño","orcid":"0000-0002-3150-0118","position":4,"is_corresponding":false},{"id":400477,"name":"Hortensia Álvarez","orcid":"0000-0002-5002-1737","position":5,"is_corresponding":false},{"id":401269,"name":"Nieves Valcarce","orcid":null,"position":6,"is_corresponding":false},{"id":400475,"name":"Alexandre Pérez‐González","orcid":"0000-0003-4836-6768","position":7,"is_corresponding":false},{"id":400482,"name":"Ezequiel Ruíz-Mateos","orcid":"0000-0001-6747-7813","position":8,"is_corresponding":false},{"id":344429,"name":"Leonid Margolis","orcid":"0000-0002-1960-1928","position":9,"is_corresponding":false},{"id":262177,"name":"Michael M. Lederman","orcid":"0000-0001-9247-8025","position":10,"is_corresponding":false},{"id":333577,"name":"Michael L. Freeman","orcid":"0000-0002-7690-5258","position":11,"is_corresponding":false},{"id":400472,"name":"Eva Poveda","orcid":"0000-0003-4835-9875","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T02:01:42.089235Z","pmid":"39267749","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}