{"doi":"10.3389/fimmu.2024.1422541","title":"The role of deacetylase SIRT1 in allergic diseases","abstract":"<jats:p>The silent information regulator sirtuin 1 (SIRT1) protein is an NAD<jats:sup>+</jats:sup>-dependent class-III lysine deacetylase that serves as an important post-transcriptional modifier targeting lysine acetylation sites to mediate deacetylation modifications of histones and non-histone proteins. SIRT1 has been reported to be involved in several physiological or pathological processes such as aging, inflammation, immune responses, oxidative stress and allergic diseases. In this review, we summarized the regulatory roles of SIRT1 during allergic disorder progression. Furthermore, we highlight the therapeutic effects of targeting SIRT1 in allergic diseases.</jats:p>","journal":"Frontiers in Immunology","year":2024,"id":597232,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1438253,"name":"Xinyi Tang","orcid":"0009-0000-8293-9086","position":1,"is_corresponding":false},{"id":1070469,"name":"Wenxin Wang","orcid":"0000-0002-5053-0611","position":2,"is_corresponding":false},{"id":291088,"name":"Jun Yang","orcid":"0000-0001-8126-1728","position":3,"is_corresponding":false},{"id":35912,"name":"Shengjun Wang","orcid":"0000-0001-6584-1183","position":4,"is_corresponding":false},{"id":394928,"name":"Yun Lu","orcid":"0000-0002-6450-9813","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of deacetylase SIRT1 in allergic diseases","abstract":"<jats:p>The silent information regulator sirtuin 1 (SIRT1) protein is an NAD<jats:sup>+</jats:sup>-dependent class-III lysine deacetylase that serves as an important post-transcriptional modifier targeting lysine acetylation sites to mediate deacetylation modifications of histones and non-histone proteins. SIRT1 has been reported to be involved in several physiological or pathological processes such as aging, inflammation, immune responses, oxidative stress and allergic diseases. In this review, we summarized the regulatory roles of SIRT1 during allergic disorder progression. Furthermore, we highlight the therapeutic effects of targeting SIRT1 in allergic diseases.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39081309","pmcid":"PMC11286408","openalex_id":"https://openalex.org/W4400695819","authors":[],"funders":[],"total_grants":0,"fwci":1.6098,"citation_percentile":0.82475158,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1422541/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1422541/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2024.1422541/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fimmu.2024.1422541","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39081309","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11286408","host_type":"repository"},{"url":"https://doaj.org/article/6b7070237fa442ea909e8d0d90f6b6dd","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11286408/pdf/fimmu-15-1422541.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11286408","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11286408?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Sirtuins and Resveratrol in Medicine","Tryptophan and brain disorders","Medicinal Plants and Bioactive Compounds","Sirtuin 1","Humans","Hypersensitivity","Animals","Acetylation"],"mesh_terms":["Acetylation","Animals","Humans","Hypersensitivity","Sirtuin 1"],"keywords":["Sirtuin","Sirtuin 1","Regulator","NAD+ kinase","SIRT3","SIRT2","Medicine","Computational biology","Immunology","Biology","Genetics","Biochemistry","Enzyme","Downregulation and upregulation","Gene","Acetylation","Hypersensitivity","Allergic diseases","Deacetylase","Silent Information Regulator Sirtuin 1 (Sirt1)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T12:41:04.606894Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}