{"doi":"10.3389/fimmu.2024.1409238","title":"Tumor glucose metabolism and the T cell glycocalyx: implication for T cell function","abstract":"<jats:p>The T cell is an immune cell subset highly effective in eliminating cancer cells. Cancer immunotherapy empowers T cells and occupies a solid position in cancer treatment. The response rate, however, remains relatively low (&amp;lt;30%). The efficacy of immunotherapy is highly dependent on T cell infiltration into the tumor microenvironment (TME) and the ability of these infiltrated T cells to sustain their function within the TME. A better understanding of the inhibitory impact of the TME on T cells is crucial to improve cancer immunotherapy. Tumor cells are well described for their switch into aerobic glycolysis (Warburg effect), resulting in high glucose consumption and a metabolically distinct TME. Conversely, glycosylation, a predominant posttranslational modification of proteins, also relies on glucose molecules. Proper glycosylation of T cell receptors influences the immunological synapse between T cells and tumor cells, thereby affecting T cell effector functions including their cytolytic and cytostatic activities. This review delves into the complex interplay between tumor glucose metabolism and the glycocalyx of T cells, shedding light on how the TME can induce alterations in the T cell glycocalyx, which can subsequently influence the T cell’s ability to target and eliminate tumor cells.</jats:p>","journal":"Frontiers in Immunology","year":2024,"id":314623,"datarank":0.5539718131408439,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.15811321369855497,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.15811321369855497,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":12,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1013549,"name":"Kyra E. Wagemans","orcid":null,"position":1,"is_corresponding":false},{"id":624145,"name":"Gosse J. Adema","orcid":"0000-0002-6750-1665","position":2,"is_corresponding":false},{"id":1013550,"name":"Lenneke A. M. Cornelissen","orcid":null,"position":3,"is_corresponding":false},{"id":1013548,"name":"Fabian Schuurmans","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Tumor glucose metabolism and the T cell glycocalyx: implication for T cell function","abstract":"<jats:p>The T cell is an immune cell subset highly effective in eliminating cancer cells. Cancer immunotherapy empowers T cells and occupies a solid position in cancer treatment. The response rate, however, remains relatively low (&amp;lt;30%). The efficacy of immunotherapy is highly dependent on T cell infiltration into the tumor microenvironment (TME) and the ability of these infiltrated T cells to sustain their function within the TME. A better understanding of the inhibitory impact of the TME on T cells is crucial to improve cancer immunotherapy. Tumor cells are well described for their switch into aerobic glycolysis (Warburg effect), resulting in high glucose consumption and a metabolically distinct TME. Conversely, glycosylation, a predominant posttranslational modification of proteins, also relies on glucose molecules. Proper glycosylation of T cell receptors influences the immunological synapse between T cells and tumor cells, thereby affecting T cell effector functions including their cytolytic and cytostatic activities. This review delves into the complex interplay between tumor glucose metabolism and the glycocalyx of T cells, shedding light on how the TME can induce alterations in the T cell glycocalyx, which can subsequently influence the T cell’s ability to target and eliminate tumor cells.</jats:p>","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38881904","pmcid":null,"openalex_id":"https://openalex.org/W4399246923","authors":[],"funders":[{"funder_name":"KWF Kankerbestrijding","grant_id":"15326, 11266","title":null}],"total_grants":1,"fwci":2.2433,"citation_percentile":0.89183197,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1409238/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1409238/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2024.1409238/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fimmu.2024.1409238","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38881904","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11176483","host_type":"repository"},{"url":"https://hdl.handle.net/2066/307812","host_type":"repository"},{"url":"https://doaj.org/article/a630afd5daf4418ca943b370e79f88a0","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11176483/pdf/fimmu-15-1409238.pdf","host_type":"repository"},{"url":"https://repository.ubn.ru.nl//bitstream/handle/2066/307812/307812.pdf","host_type":"repository"}],"fields_of_study":["Cancer, Hypoxia, and Metabolism","Erythrocyte Function and Pathophysiology","Metabolism, Diabetes, and Cancer"],"mesh_terms":["Warburg Effect, Oncologic","Animals","Glucose","Glycolysis","Glycosylation","Humans","Immunotherapy","Neoplasms","T-Lymphocytes","Glycocalyx","Tumor Microenvironment"],"keywords":["Glycocalyx","Cell metabolism","Metabolism","Function (biology)","Cell function","Carbohydrate metabolism","Cell","Cell biology","Chemistry","Biology","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-19T00:49:01.943916Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}