{"doi":"10.3389/fimmu.2024.1358477","title":"Early B cell transcriptomic markers of measles-specific humoral immunity following a 3rd dose of MMR vaccine","abstract":"B cell transcriptomic signatures hold promise for the early prediction of vaccine-induced humoral immunity and vaccine protective efficacy. We performed a longitudinal study in 232 healthy adult participants before/after a 3 rd dose of MMR (MMR3) vaccine. We assessed baseline and early transcriptional patterns in purified B cells and their association with measles-specific humoral immunity after MMR vaccination using two analytical methods (“per gene” linear models and joint analysis). Our study identified distinct early transcriptional signatures/genes following MMR3 that were associated with measles-specific neutralizing antibody titer and/or binding antibody titer. The most significant genes included: the interleukin 20 receptor subunit beta/ IL20RB gene (a subunit receptor for IL-24, a cytokine involved in the germinal center B cell maturation/response); the phorbol-12-myristate-13-acetate-induced protein 1/ PMAIP1 , the brain expressed X-linked 2/ BEX2 gene and the B cell Fas apoptotic inhibitory molecule/ FAIM , involved in the selection of high-affinity B cell clones and apoptosis/regulation of apoptosis; as well as IL16 (encoding the B lymphocyte-derived IL-16 ligand of CD4), involved in the crosstalk between B cells, dendritic cells and helper T cells. Significantly enriched pathways included B cell signaling, apoptosis/regulation of apoptosis, metabolic pathways, cell cycle-related pathways, and pathways associated with viral infections, among others. In conclusion, our study identified genes/pathways linked to antigen-induced B cell proliferation, differentiation, apoptosis, and clonal selection, that are associated with, and impact measles virus-specific humoral immunity after MMR vaccination.","journal":"Frontiers in Immunology","year":2024,"id":465207,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":252214,"name":"Jun Chen","orcid":"0000-0002-1273-5624","position":1,"is_corresponding":false},{"id":916316,"name":"Huy Quang Quach","orcid":"0000-0003-2191-5771","position":2,"is_corresponding":false},{"id":917660,"name":"Tamar Ratishvili","orcid":"0000-0002-1446-1188","position":3,"is_corresponding":false},{"id":374144,"name":"Nathaniel D. Warner","orcid":"0000-0001-9584-5257","position":4,"is_corresponding":false},{"id":275824,"name":"Inna G. Ovsyannikova","orcid":"0000-0003-1506-9214","position":5,"is_corresponding":false},{"id":275825,"name":"Gregory A. Poland","orcid":"0000-0001-5057-4457","position":6,"is_corresponding":false},{"id":275823,"name":"Richard B. Kennedy","orcid":"0000-0001-6164-4967","position":7,"is_corresponding":false},{"id":495327,"name":"Iana H. Haralambieva","orcid":"0000-0002-2856-0590","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:04:46.201722Z","pmid":"38633249","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}