{"doi":"10.3389/fimmu.2024.1277526","title":"Co-formulation of the rF1V plague vaccine with depot-formulated cytokines enhances immunogenicity and efficacy to elicit protective responses against aerosol challenge in mice","abstract":"This study evaluated a depot-formulated cytokine-based adjuvant to improve the efficacy of the recombinant F1V (rF1V) plague vaccine and examined the protective response following aerosol challenge in a murine model. The results of this study showed that co-formulation of the Alhydrogel-adsorbed rF1V plague fusion vaccine with the depot-formulated cytokines recombinant human interleukin 2 (rhuIL-2) and/or recombinant murine granulocyte macrophage colony-stimulating factor (rmGM-CSF) significantly enhances immunogenicity and significant protection at lower antigen doses against a lethal aerosol challenge. These results provide additional support for the co-application of the depot-formulated IL-2 and/or GM-CSF cytokines to enhance vaccine efficacy.","journal":"Frontiers in Immunology","year":2024,"id":475578,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":727316,"name":"Jiahui Li","orcid":"0000-0002-9597-737X","position":1,"is_corresponding":false},{"id":927922,"name":"Nguyen X. Nguyen","orcid":"0000-0002-8153-7779","position":2,"is_corresponding":false},{"id":928388,"name":"Frank W. Falkenberg","orcid":null,"position":3,"is_corresponding":false},{"id":954630,"name":"Lisa N. Henning","orcid":null,"position":4,"is_corresponding":false},{"id":954631,"name":"Robert Krile","orcid":null,"position":5,"is_corresponding":false},{"id":945647,"name":"Ying-Liang Chou","orcid":null,"position":6,"is_corresponding":false},{"id":927923,"name":"James N. Herron","orcid":"0000-0002-8298-0537","position":7,"is_corresponding":false},{"id":566307,"name":"J. Scott Hale","orcid":"0000-0003-4318-8472","position":8,"is_corresponding":false},{"id":374047,"name":"E. Diane Williamson","orcid":"0000-0002-0322-5972","position":9,"is_corresponding":false},{"id":928385,"name":"Darrell R. Galloway","orcid":null,"position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T02:06:21.071690Z","pmid":"38605961","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}