{"doi":"10.3389/fimmu.2023.1250316","title":"The promiscuous development of an unconventional Qa1b-restricted T cell population","abstract":"MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and specificity remain poorly understood. Here we focus on a CD8 T cell population reactive to a self-peptide (FL9) bound to mouse MHC-E (Qa-1 b ) that is presented in response to loss of the MHC I processing enzyme ERAAP, termed QFL T cells. We find that mature QFL thymocytes are predominantly CD8αβ+CD4-, show signs of agonist selection, and give rise to both CD8αα and CD8αβ intraepithelial lymphocytes (IEL), as well as memory phenotype CD8αβ T cells. QFL T cells require the MHC I subunit β-2 microglobulin (β2m), but do not require Qa1 b or classical MHC I for positive selection. However, QFL thymocytes do require Qa1 b for agonist selection and full functionality. Our data highlight the relaxed requirements for positive selection of an MHC-E restricted T cell population and suggest a CD8αβ+CD4- pathway for development of CD8αα IELs.","journal":"Frontiers in Immunology","year":2023,"id":355940,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1086246,"name":"Kathya Arana","orcid":null,"position":1,"is_corresponding":false},{"id":729600,"name":"Jian Guan","orcid":"0000-0002-0118-6578","position":2,"is_corresponding":false},{"id":373175,"name":"Shiao Wei Chan","orcid":null,"position":3,"is_corresponding":false},{"id":1104284,"name":"Xiaokun Yang","orcid":"0000-0003-0234-1143","position":4,"is_corresponding":false},{"id":238814,"name":"Nadia S. Kurd","orcid":null,"position":5,"is_corresponding":false},{"id":633501,"name":"Angus Lee","orcid":null,"position":6,"is_corresponding":false},{"id":729602,"name":"Nilabh Shastri","orcid":"0000-0002-8060-3025","position":7,"is_corresponding":false},{"id":561536,"name":"Laurent Coscoy","orcid":"0000-0002-7337-2345","position":8,"is_corresponding":false},{"id":372451,"name":"Ellen A. Robey","orcid":"0000-0002-3630-5266","position":9,"is_corresponding":false},{"id":1104168,"name":"Michael Manoharan Valerio","orcid":"0000-0002-7815-3774","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T01:13:21.145955Z","pmid":"38022509","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}