{"doi":"10.3389/fimmu.2023.1200167","title":"Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity","abstract":"Objective: There is an urgent need for novel biomarkers in lupus nephritis (LN). We report a non-invasive urinary biomarker, L-selectin, in two independent multi-ethnic cohorts. Methods: uL-selectin was tested cross-sectionally in a Chinese cohort (n=255) and a US cohort (n=219) of SLE patients and controls using ELISA. A longitudinal cohort includes 20 active Chinese LN patients. Results: uL-selectin was significantly increased in active LN patients compared to active non-renal SLE, inactive LN, inactive non-renal SLE, chronic kidney disease patients, and healthy controls. uL-selectin positively correlated with global and renal disease activities as well as histological activity index and chronicity index (CI). Low uL-selectin was an independent predictor for high CI. During follow-up, uL-selectin levels decreased significantly in the complete renal remission group. Conclusion: uL-selectin is a novel biomarker of disease activity and renal histopathology in LN across multiple ethnicities. It also reflects treatment response in LN patients during follow up.","journal":"Frontiers in Immunology","year":2023,"id":366015,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9331,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":278760,"name":"Kamala Vanarsa","orcid":"0000-0002-7602-4709","position":1,"is_corresponding":false},{"id":129763,"name":"Zhihua Yin","orcid":"0000-0003-0850-680X","position":2,"is_corresponding":false},{"id":278764,"name":"Ting Zhang","orcid":"0000-0002-8616-9733","position":3,"is_corresponding":false},{"id":918037,"name":"Jessica Castillo","orcid":null,"position":4,"is_corresponding":false},{"id":443738,"name":"Min Dai","orcid":"0000-0002-1681-6990","position":5,"is_corresponding":false},{"id":1122741,"name":"Linghua Zou","orcid":null,"position":6,"is_corresponding":false},{"id":418846,"name":"Ling Qin","orcid":"0000-0001-8717-3833","position":7,"is_corresponding":false},{"id":1122742,"name":"Jieying Wang","orcid":null,"position":8,"is_corresponding":false},{"id":1122231,"name":"Qiang Guo","orcid":"0000-0002-0605-7804","position":9,"is_corresponding":false},{"id":278768,"name":"Ramesh Saxena","orcid":"0000-0001-5722-9509","position":10,"is_corresponding":false},{"id":278767,"name":"Michelle Petri","orcid":"0000-0003-1441-5373","position":11,"is_corresponding":false},{"id":250985,"name":"Nan Shen","orcid":"0000-0002-5875-4417","position":12,"is_corresponding":false},{"id":1122743,"name":"Zhizhong Ye","orcid":null,"position":13,"is_corresponding":false},{"id":278769,"name":"Chandra Mohan","orcid":"0000-0001-7896-5740","position":14,"is_corresponding":false},{"id":250955,"name":"Huihua Ding","orcid":"0000-0002-7530-8953","position":15,"is_corresponding":false},{"id":1122230,"name":"Yiwei Shen","orcid":"0000-0003-4594-5035","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T01:14:55.198227Z","pmid":"37720233","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}