{"doi":"10.3389/fimmu.2022.984302","title":"Regulation of T-independent B-cell responses by microRNA-146a","abstract":"The microRNA, miR-146a, is a negative feedback regulator of the central immune transcription factor, nuclear factor kappa B (NFkB). MiR-146a plays important roles in the immune system, and miR-146a deficient mice show a complex phenotype with features of chronic inflammation and autoimmune disease. In this study, we examined the role of miR-146a in extrafollicular B-cell responses, finding that miR-146a suppresses cellular responses in vivo and in vitro . Gene expression profiling revealed that miR-146a-deficient B-cells showed upregulation of interferon pathway genes, including Traf6 , a known miR-146a target. We next interrogated the role of TRAF6 in these B-cell responses, finding that TRAF6 is required for proliferation by genetic and pharmacologic inhibition. Together, our findings demonstrate a novel role for miR-146a and TRAF6 in the extrafollicular B-cell responses, which have recently been tied to autoimmune disease pathogenesis. Our work highlights the pathogenetic role of miR-146a and the potential of pharmacologic inhibition of TRAF6 in autoimmune diseases in which miR-146a is deregulated.","journal":"Frontiers in Immunology","year":2022,"id":282671,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":586913,"name":"Tiffany Tran","orcid":"0000-0003-2163-3520","position":1,"is_corresponding":false},{"id":587450,"name":"May Paing","orcid":null,"position":2,"is_corresponding":false},{"id":958665,"name":"Yuxin Yin","orcid":"0000-0003-4102-0043","position":3,"is_corresponding":false},{"id":683016,"name":"Amit Kumar Jaiswal","orcid":"0000-0002-6566-3580","position":4,"is_corresponding":false},{"id":959109,"name":"Ching-Hsuan Tso","orcid":null,"position":5,"is_corresponding":false},{"id":958666,"name":"Koushik Roy","orcid":"0000-0002-9525-7196","position":6,"is_corresponding":false},{"id":36321,"name":"David Casero","orcid":"0000-0002-7347-3330","position":7,"is_corresponding":false},{"id":393189,"name":"Dinesh S. Rao","orcid":"0000-0002-0794-9337","position":8,"is_corresponding":false},{"id":586916,"name":"Jennifer K. King","orcid":"0000-0002-1001-6044","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:29:19.691592Z","pmid":"36172375","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}