{"doi":"10.3389/fimmu.2022.906499","title":"CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells","abstract":"CD5 is constitutively expressed on all T cells and is a negative regulator of lymphocyte function. However, the full extent of CD5 function in immunity remains unclear. CD5 deficiency impacts thymic selection and extra-thymic regulatory T cell generation, yet CD5 knockout was reported to cause no immune pathology. Here we show that CD5 is a key modulator of gut immunity. We generated mice with inducible CD5 knockdown (KD) in the autoimmune-prone nonobese diabetic (NOD) background. CD5 deficiency caused T cell-dependent wasting disease driven by chronic gut immune dysregulation. CD5 inhibition also exacerbated acute experimental colitis. Mechanistically, loss of CD5 increased phospho-Stat3 levels, leading to elevated IL-17A secretion. Our data reveal a new facet of CD5 function in shaping the T cell cytokine profile.","journal":"Frontiers in Immunology","year":2022,"id":290100,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":256180,"name":"Badr Kiaf","orcid":"0000-0001-8194-7543","position":1,"is_corresponding":false},{"id":972116,"name":"Teri Hatzihristidis","orcid":"0000-0001-9694-5532","position":2,"is_corresponding":false},{"id":972542,"name":"Anna Ruckdeschel","orcid":null,"position":3,"is_corresponding":false},{"id":972117,"name":"Janice M Nieves-Bonilla","orcid":"0000-0001-6543-3681","position":4,"is_corresponding":false},{"id":972118,"name":"Yuki Ishikawa","orcid":"0000-0002-6514-8239","position":5,"is_corresponding":false},{"id":381651,"name":"Bin Zhao","orcid":"0000-0001-7065-2416","position":6,"is_corresponding":false},{"id":972119,"name":"Peilin Zheng","orcid":"0000-0002-4712-4903","position":7,"is_corresponding":false},{"id":341213,"name":"Paul E. Love","orcid":"0000-0002-6682-7372","position":8,"is_corresponding":false},{"id":559321,"name":"Stephan Kissler","orcid":"0000-0003-3062-7800","position":9,"is_corresponding":false},{"id":972115,"name":"Cornelia Schuster","orcid":"0000-0003-2665-9527","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T00:30:26.667578Z","pmid":"35720357","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}