{"doi":"10.3389/fimmu.2022.880190","title":"Differences in SARS-CoV-2 Vaccine Response Dynamics Between Class-I- and Class-II-Specific T-Cell Receptors in Inflammatory Bowel Disease","abstract":"T-cells specifically bind antigens to induce adaptive immune responses using highly specific molecular recognition, and a diverse T-cell repertoire with expansion of antigen-specific clones can indicate robust immune responses after infection or vaccination. For patients with inflammatory bowel disease (IBD), a spectrum of chronic intestinal inflammatory diseases usually requiring immunomodulatory treatment, the T-cell response has not been well characterized. Understanding the patient factors that result in strong vaccination responses is critical to guiding vaccination schedules and identifying mechanisms of T-cell responses in IBD and other immune-mediated conditions. Here we used T-cell receptor sequencing to show that T-cell responses in an IBD cohort were influenced by demographic and immune factors, relative to a control cohort of health care workers (HCWs). Subjects were sampled at the time of SARS-CoV-2 vaccination, and longitudinally afterwards; TCR Vβ gene repertoires were sequenced and analyzed for COVID-19-specific clones. We observed significant differences in the overall strength of the T-cell response by age and vaccine type. We further stratified the T-cell response into Class-I- and Class-II-specific responses, showing that Ad26.COV2.S vector vaccine induced Class-I-biased T-cell responses, whereas mRNA vaccine types led to different responses, with mRNA-1273 vaccine inducing a more Class-I-deficient T-cell response compared to BNT162b2. Finally, we showed that these T-cell patterns were consistent with antibody levels from the same patients. Our results account for the surprising success of vaccination in nominally immuno-compromised IBD patients, while suggesting that a subset of IBD patients prone to deficiencies in T-cell response may warrant enhanced booster protocols.","journal":"Frontiers in Immunology","year":2022,"id":280138,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":271379,"name":"Dalin Li","orcid":"0000-0003-4738-0074","position":1,"is_corresponding":false},{"id":218312,"name":"Joseph E. Ebinger","orcid":"0000-0002-0587-1572","position":2,"is_corresponding":false},{"id":414153,"name":"Emebet Mengesha","orcid":"0000-0001-7830-1557","position":3,"is_corresponding":false},{"id":406943,"name":"Rebecca Elyanow","orcid":"0000-0001-8877-7188","position":4,"is_corresponding":false},{"id":551172,"name":"Rachel Gittelman","orcid":null,"position":5,"is_corresponding":false},{"id":954185,"name":"Heidi Chapman","orcid":"0000-0001-8970-0262","position":6,"is_corresponding":false},{"id":644746,"name":"Sandy Joung","orcid":"0000-0002-7582-3218","position":7,"is_corresponding":false},{"id":343612,"name":"Gregory J. Botwin","orcid":null,"position":8,"is_corresponding":false},{"id":954186,"name":"Valeriya Pozdnyakova","orcid":"0000-0003-0764-0038","position":9,"is_corresponding":false},{"id":622816,"name":"Philip Debbas","orcid":"0000-0002-7220-2117","position":10,"is_corresponding":false},{"id":954187,"name":"Angela Mujukian","orcid":"0000-0002-8785-9808","position":11,"is_corresponding":false},{"id":252823,"name":"John C. Prostko","orcid":null,"position":12,"is_corresponding":false},{"id":615441,"name":"Edwin C. Frias","orcid":"0000-0002-7058-2240","position":13,"is_corresponding":false},{"id":616944,"name":"James L. Stewart","orcid":null,"position":14,"is_corresponding":false},{"id":954601,"name":"Arash Horizon","orcid":null,"position":15,"is_corresponding":false},{"id":553328,"name":"Noah Merin","orcid":null,"position":16,"is_corresponding":false},{"id":257448,"name":"Kimia Sobhani","orcid":"0000-0002-9297-3445","position":17,"is_corresponding":false},{"id":104598,"name":"Jane C. Figueiredo","orcid":"0000-0002-2452-3194","position":18,"is_corresponding":false},{"id":270108,"name":"Susan Cheng","orcid":"0000-0002-4977-036X","position":19,"is_corresponding":false},{"id":550135,"name":"Ian M. Kaplan","orcid":"0000-0002-7140-880X","position":20,"is_corresponding":false},{"id":1090,"name":"Dermot McGovern","orcid":"0000-0001-5621-759X","position":21,"is_corresponding":false},{"id":416183,"name":"Akil Merchant","orcid":"0000-0001-7472-822X","position":22,"is_corresponding":false},{"id":395673,"name":"Gil Melmed","orcid":"0000-0002-2591-5165","position":23,"is_corresponding":false},{"id":257447,"name":"Jonathan Braun","orcid":"0000-0003-1646-2974","position":24,"is_corresponding":false},{"id":109710,"name":"Alexander M. Xu","orcid":"0000-0003-4877-4358","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T00:28:59.341002Z","pmid":"35464463","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}