{"doi":"10.3389/fimmu.2022.868679","title":"Cardiovascular Dysfunction in COVID-19: Association Between Endothelial Cell Injury and Lactate","abstract":"Coronavirus disease 2019 (COVID-19), an infectious respiratory disease propagated by a new virus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has resulted in global healthcare crises. Emerging evidence from patients with COVID-19 suggests that endothelial cell damage plays a central role in COVID-19 pathogenesis and could be a major contributor to the severity and mortality of COVID-19. Like other infectious diseases, the pathogenesis of COVID-19 is closely associated with metabolic processes. Lactate, a potential biomarker in COVID-19, has recently been shown to mediate endothelial barrier dysfunction. In this review, we provide an overview of cardiovascular injuries and metabolic alterations caused by SARS-CoV-2 infection. We also propose that lactate plays a potential role in COVID-19-driven endothelial cell injury.","journal":"Frontiers in Immunology","year":2022,"id":256232,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9602,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":905101,"name":"Matthew T. Holt","orcid":"0009-0003-0685-1543","position":1,"is_corresponding":false},{"id":237153,"name":"Min Fan","orcid":"0000-0002-1787-4287","position":2,"is_corresponding":false},{"id":108152,"name":"Victor L. Lam","orcid":"0000-0001-5384-6542","position":3,"is_corresponding":false},{"id":374814,"name":"Yong Yang","orcid":"0000-0002-4612-9219","position":4,"is_corresponding":false},{"id":237156,"name":"Tuanzhu Ha","orcid":"0000-0001-8244-4585","position":5,"is_corresponding":false},{"id":225206,"name":"David L. Williams","orcid":"0000-0002-4586-9290","position":6,"is_corresponding":false},{"id":237157,"name":"Chuanfu Li","orcid":"0000-0002-1224-4358","position":7,"is_corresponding":false},{"id":409263,"name":"Xiaohui Wang","orcid":"0000-0002-3415-5612","position":8,"is_corresponding":false},{"id":339210,"name":"Kun Yang","orcid":"0000-0002-6232-6271","position":0,"is_corresponding":true}],"reference_count":218,"raw_metadata":null,"created_at":"2026-07-19T00:25:21.336200Z","pmid":"35401579","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}