{"doi":"10.3389/fimmu.2022.847092","title":"Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response","abstract":"Certain CD8 T cell responses are particularly effective at controlling infection, as exemplified by elite control of HIV in individuals harboring HLA-B57. To understand the structural features that contribute to CD8 T cell elite control, we focused on a strongly protective CD8 T cell response directed against a parasite-derived peptide (HF10) presented by an atypical MHC-I molecule, H-2Ld. This response exhibits a focused TCR repertoire dominated by Vβ2, and a representative TCR (TG6) in complex with Ld-HF10 reveals an unusual structure in which both MHC and TCR contribute extensively to peptide specificity, along with a parallel footprint of TCR on its pMHC ligand. The parallel footprint is a common feature of Vβ2-containing TCRs and correlates with an unusual Vα-Vβ interface, CDR loop conformations, and Vβ2-specific germline contacts with peptides. Vβ2 and Ld may represent \"specialist\" components for antigen recognition that allows for particularly strong and focused T cell responses.","journal":"Frontiers in Immunology","year":2022,"id":292044,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":513522,"name":"Alexandra Tsitsiklis","orcid":"0000-0003-3467-1171","position":1,"is_corresponding":false},{"id":662514,"name":"Stephanie Devoe","orcid":null,"position":2,"is_corresponding":false},{"id":975724,"name":"Wei Gao","orcid":"0000-0002-5043-6692","position":3,"is_corresponding":false},{"id":976209,"name":"Hunghao Chu","orcid":null,"position":4,"is_corresponding":false},{"id":975725,"name":"Yan Zhang","orcid":"0000-0002-4091-1365","position":5,"is_corresponding":false},{"id":693751,"name":"Wei Li","orcid":"0009-0003-4681-4923","position":6,"is_corresponding":false},{"id":975726,"name":"Wing Ki Wong","orcid":"0000-0003-4029-6902","position":7,"is_corresponding":false},{"id":975727,"name":"Charlotte M. Deane","orcid":"0000-0003-1388-2252","position":8,"is_corresponding":false},{"id":244202,"name":"David B. Neau","orcid":null,"position":9,"is_corresponding":false},{"id":310833,"name":"Jill E. Slansky","orcid":"0000-0003-3820-1724","position":10,"is_corresponding":false},{"id":225737,"name":"Paul G. Thomas","orcid":"0000-0001-7955-0256","position":11,"is_corresponding":false},{"id":372451,"name":"Ellen A. Robey","orcid":"0000-0002-3630-5266","position":12,"is_corresponding":false},{"id":455530,"name":"Shaodong Dai","orcid":"0000-0003-4760-2773","position":13,"is_corresponding":false},{"id":661582,"name":"Yang Wang","orcid":"0000-0002-6510-6653","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T00:30:42.221508Z","pmid":"35967379","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}