{"doi":"10.3389/fimmu.2022.817345","title":"Persistence of SARS-CoV-2 Antibodies in Vaccinated Health Care Workers Analyzed by Coronavirus Antigen Microarray","abstract":"Recent studies provide conflicting evidence on the persistence of SARS-CoV-2 immunity induced by mRNA vaccines. Here, we aim to quantify the persistence of humoral immunity following vaccination using a coronavirus antigen microarray that includes 10 SARS-CoV-2 antigens. In a prospective longitudinal cohort of 240 healthcare workers, composite SARS-CoV-2 IgG antibody levels did not wane significantly over a 6-month study period. In the subset of the study population previously exposed to SARS-CoV-2 based on seropositivity for nucleocapsid antibodies, higher composite anti-spike IgG levels were measured before the vaccine but no significant difference from unexposed individuals was observed at 6 months. Age, vaccine type, or worker role did not significantly impact composite IgG levels, although non-significant trends towards lower antibody levels in older participants and higher antibody levels with Moderna vaccine were observed at 6 months. A small subset of our cohort were classified as having waning antibody titers at 6 months, and these individuals were less likely to work in patient care roles and more likely to have prior exposure to SARS-CoV-2.","journal":"Frontiers in Immunology","year":2022,"id":276437,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":643548,"name":"Kathleen Powers","orcid":null,"position":1,"is_corresponding":false},{"id":642320,"name":"Milind Vasudev","orcid":"0000-0003-0754-3115","position":2,"is_corresponding":false},{"id":565921,"name":"Anton M. 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Obiero","orcid":"0000-0001-9741-512X","position":15,"is_corresponding":false},{"id":893382,"name":"Emily Silzel","orcid":null,"position":16,"is_corresponding":false},{"id":381281,"name":"Rie Nakajima","orcid":"0000-0002-1986-9086","position":17,"is_corresponding":false},{"id":947500,"name":"William Thomas Gombrich","orcid":null,"position":18,"is_corresponding":false},{"id":459999,"name":"Algis Jasinskas","orcid":null,"position":19,"is_corresponding":false},{"id":391804,"name":"Frank Zaldivar","orcid":null,"position":20,"is_corresponding":false},{"id":565919,"name":"Sebastian D. Schubl","orcid":"0000-0001-9431-7735","position":21,"is_corresponding":false},{"id":104930,"name":"Philip L. 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