{"doi":"10.3389/fimmu.2022.1088024","title":"Placental galectins regulate innate and adaptive immune responses in pregnancy","abstract":"Introduction: Galectins are master regulators of maternal immune responses and placentation in pregnancy. Galectin-13 (gal-13) and galectin-14 (gal-14) are expressed solely by the placenta and contribute to maternal-fetal immune tolerance by inducing the apoptosis of activated T lymphocytes and the polarization of neutrophils toward an immune-regulatory phenotype.Furthermore, their decreased placental expression is associated with pregnancy complications, such as preeclampsia and miscarriage. Yet, our knowledge of the immunoregulatory role of placental galectins is incomplete. Methods: This study aimed to investigate the effects of recombinant gal-13 and gal-14 on cell viability, apoptosis, and cytokine production of peripheral blood mononuclear cells (PBMCs) and the signaling pathways involved. Results: Herein, we show that gal-13 and gal-14 bind to the surface of non-activated PBMCs (monocytes, natural killer cells, B cells, and T cells) and increase their viability while decreasing the rate of their apoptosis without promoting cell proliferation. We also demonstrate that gal-13 and gal-14 induce the production of interleukin (IL)-8, IL-10, and interferon-gamma cytokines in a concentration-dependent manner in PBMCs. The parallel activation of Erk1/2, p38, and NF-ĸB signaling evidenced by kinase phosphorylation in PBMCs suggests the involvement of these pathways in the regulation of the galectin-affected immune cell functions. Discussion: These findings provide further evidence on how placenta-specific galectins assist in the establishment and maintenance of a proper immune environment during a healthy pregnancy.","journal":"Frontiers in Immunology","year":2022,"id":266327,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236857,"name":"Roberto Romero","orcid":"0000-0002-4448-5121","position":1,"is_corresponding":false},{"id":465453,"name":"Eszter Tóth","orcid":"0000-0001-7149-1482","position":2,"is_corresponding":false},{"id":926455,"name":"Judit Kapitány","orcid":null,"position":3,"is_corresponding":false},{"id":861110,"name":"Máté Posta","orcid":null,"position":4,"is_corresponding":false},{"id":841295,"name":"Dahiana M. Gallo","orcid":"0000-0001-8150-6457","position":5,"is_corresponding":false},{"id":465456,"name":"Simona W. Rossi","orcid":"0000-0002-8212-0502","position":6,"is_corresponding":false},{"id":236858,"name":"Adi L. Tarca","orcid":"0000-0003-1712-7588","position":7,"is_corresponding":false},{"id":344144,"name":"Offer Erez","orcid":"0000-0002-2213-8129","position":8,"is_corresponding":false},{"id":465393,"name":"Zoltán Papp","orcid":"0000-0002-7532-9703","position":9,"is_corresponding":false},{"id":901036,"name":"János Matkó","orcid":"0000-0001-9434-934X","position":10,"is_corresponding":false},{"id":344145,"name":"Nándor Gábor Than","orcid":"0000-0001-9385-7019","position":11,"is_corresponding":false},{"id":465452,"name":"Andrea Balogh","orcid":"0000-0003-0322-1522","position":12,"is_corresponding":false},{"id":901033,"name":"Orsolya Oravecz","orcid":"0000-0002-7342-183X","position":0,"is_corresponding":true}],"reference_count":132,"raw_metadata":null,"created_at":"2026-07-19T00:26:54.081997Z","pmid":"36643922","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}