{"doi":"10.3389/fimmu.2022.1047661","title":"After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism","abstract":"CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is known to play an important role in host defense and immunopathology, its impact on naïve CD8 T cells remains underappreciated. Here we report that exposure to reovirus, both in vitro or in vivo , promotes bystander activation of naïve CD8 T cells within 24 hours and that this distinct subtype of CD8 T cell displays an innate, antiviral, type I interferon sensitized signature. The induction of bystander naïve CD8 T cells is STAT1 dependent and regulated through nicotinamide phosphoribosyl transferase (NAMPT)-mediated enzymatic actions within NAD + salvage metabolic biosynthesis. These findings identify a novel aspect of CD8 T cell activation following virus infection with implications for human health and physiology.","journal":"Frontiers in Immunology","year":2023,"id":365160,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1121105,"name":"Barry E. Kennedy","orcid":null,"position":1,"is_corresponding":false},{"id":742202,"name":"J. Patrick Murphy","orcid":"0000-0003-4074-359X","position":2,"is_corresponding":false},{"id":275941,"name":"Prathyusha Konda","orcid":"0000-0002-6861-4442","position":3,"is_corresponding":false},{"id":1120668,"name":"Michael Giacomantonio","orcid":"0000-0002-5921-2513","position":4,"is_corresponding":false},{"id":1121106,"name":"Tatjana Brauer-Chapin","orcid":null,"position":5,"is_corresponding":false},{"id":136624,"name":"Joao A. Paulo","orcid":"0000-0002-4291-413X","position":6,"is_corresponding":false},{"id":1121107,"name":"Vishnupriyan Kumar","orcid":null,"position":7,"is_corresponding":false},{"id":742201,"name":"Youra Kim","orcid":"0000-0002-9542-0651","position":8,"is_corresponding":false},{"id":1121108,"name":"Mariam Elaghil","orcid":null,"position":9,"is_corresponding":false},{"id":1120669,"name":"Gary Sisson","orcid":"0009-0006-4997-3139","position":10,"is_corresponding":false},{"id":790255,"name":"Derek R. Clements","orcid":"0000-0002-0796-8845","position":11,"is_corresponding":false},{"id":724283,"name":"Christopher T. Richardson","orcid":"0000-0002-7692-1768","position":12,"is_corresponding":false},{"id":107041,"name":"Steven P. Gygi","orcid":"0000-0001-7626-0034","position":13,"is_corresponding":false},{"id":275943,"name":"Shashi Gujar","orcid":"0000-0002-5427-0829","position":14,"is_corresponding":false},{"id":1121104,"name":"Namit Holay","orcid":null,"position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:14:46.760245Z","pmid":"36818473","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}