{"doi":"10.3389/fimmu.2022.1043375","title":"A single birth dose of Hepatitis B vaccine induces polyfunctional CD4+ T helper cells","abstract":"A single birth-dose of Hepatitis B vaccine (HepB) can protect newborns from acquiring Hepatitis B infection through vertical transmission, though several follow-up doses are required to induce long-lived protection. In addition to stimulating antibodies, a birth-dose of HepB might also induce polyfunctional CD4 + T-cells, which may contribute to initial protection. We investigated whether vaccination with HepB in the first week of life induced detectable antigen-specific CD4 + T-cells after only a single dose and following completion of the entire HepB vaccine schedule (3 doses). Using HBsAg- stimulated peripheral blood mononuclear cells from 344 infants, we detected increased populations of antigen-specific polyfunctional CD154 + IL-2 + TNFα + CD4 + T-cells following a single birth-dose of HepB in a proportion of infants. Frequencies of polyfunctional T-cells increased following the completion of the HepB schedule but increases in the proportion of responders as compared to following only one dose was marginal. Polyfunctional T-cells correlated positively with serum antibody titres following the birth dose (day30) and completion of the 3-dose primary HepB vaccine series (day 128). These data indicate that a single birth dose of HepB provides immune priming for both antigen-specific B- and T cells","journal":"Frontiers in Immunology","year":2022,"id":287828,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":266209,"name":"Alansana Darboe","orcid":"0000-0002-1152-8156","position":1,"is_corresponding":false},{"id":266205,"name":"Joann Diray‐Arce","orcid":"0000-0003-2183-4269","position":2,"is_corresponding":false},{"id":266187,"name":"Rym Ben-Othman","orcid":"0000-0002-7245-6854","position":3,"is_corresponding":false},{"id":266220,"name":"Sofia M. Vignolo","orcid":"0000-0001-8226-8083","position":4,"is_corresponding":false},{"id":967853,"name":"Shun Rao","orcid":"0000-0002-2081-6491","position":5,"is_corresponding":false},{"id":266216,"name":"Kinga K. Smolen","orcid":"0000-0001-8650-3693","position":6,"is_corresponding":false},{"id":589996,"name":"Geert Leroux‐Roels","orcid":"0000-0001-5968-2542","position":7,"is_corresponding":false},{"id":266206,"name":"Olubukola T. Idoko","orcid":"0000-0002-8802-2946","position":8,"is_corresponding":false},{"id":266214,"name":"Guzman Sánchez‐Schmitz","orcid":"0000-0002-3566-7505","position":9,"is_corresponding":false},{"id":266217,"name":"Al Ozonoff","orcid":"0000-0003-4233-5899","position":10,"is_corresponding":false},{"id":266198,"name":"Ofer Levy","orcid":"0000-0002-5859-1945","position":11,"is_corresponding":false},{"id":258306,"name":"Tobias R. Kollmann","orcid":"0000-0003-2403-9762","position":12,"is_corresponding":false},{"id":258302,"name":"Arnaud Marchant","orcid":"0000-0003-0578-0467","position":13,"is_corresponding":false},{"id":231920,"name":"Beate Kampmann","orcid":"0000-0002-6546-4709","position":14,"is_corresponding":false},{"id":398889,"name":"Julia Strandmark","orcid":null,"position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T00:30:01.051685Z","pmid":"36426360","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}