{"doi":"10.3389/fimmu.2021.810346","title":"Editorial: Neutrophil Functions in Host Immunity, Inflammation and Tissue Repair","abstract":"Neutrophil Functions in Host Immunity, Inflammation and Tissue Repair Neutrophils are the most abundant circulating leukocytes in humans and are amongst the first responders to be recruited to sites of injury and infection in response to inflammatory cues. These short-lived cells are formed by granulopoiesis in the bone marrow. Mature neutrophils are released into the circulation in a chemokine-regulated, circadian fashion (1). In the absence of stimulatory signals, neutrophils will circulate for ~1 day before becoming senescent and homing back to the bone marrow. In the presence of stimulating signals, neutrophils migrate to inflammatory sites along gradients of chemokines. Exit from blood vessels is usually selectin-and integrin-dependent, although certain sites with highly specialised vasculature (e.g., lung, liver, brain) are characterised by extravasation that is supported by alternative adhesion molecules (2). In contrast, interstitial neutrophil migration occurs in an integrin-independent fashion. Upon reaching inflammatory sites, neutrophils clear cell debris and act as the first line of cellular immunity against invading pathogens. Once their job is done, neutrophils either undergo apoptosis, releasing \"eat-me\" signals and are cleared by professional phagocytes; or can migrate away from inflamed tissues, promoting tissue healing responses. If these processes are dysregulated, neutrophils can release their toxic components into surrounding tissues, leading to bystander cell damage and chronic inflammation.","journal":"Frontiers in Immunology","year":2021,"id":214662,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":808290,"name":"Philip M. Elks","orcid":"0000-0003-1683-0749","position":1,"is_corresponding":false},{"id":659080,"name":"Felix Ellett","orcid":"0000-0003-4941-4346","position":2,"is_corresponding":false},{"id":808289,"name":"Sonja Vermeren","orcid":"0000-0002-8460-0884","position":0,"is_corresponding":true}],"reference_count":8,"raw_metadata":null,"created_at":"2026-07-18T23:52:46.604690Z","pmid":"34917100","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}