{"doi":"10.3389/fimmu.2021.797548","title":"Editorial: B Cell Activation and Differentiation: New Perspectives on an Enduring Topic","abstract":"B Cell Activation and Differentiation: New Perspectives on an Enduring Topic B lymphocytes, identified more than half a century ago, are crucial for sustained host immune responses to pathogens through differentiation into long-lived plasma cells and memory B cells, particularly those producing specific antibodies of switched immunoglobulin (Ig) isotypes (IgG, IgA, and IgE). Reflecting the diversity of microorganisms that they need to counter, B cells function as both innate and adaptive immune cells, with their activation driven or fine-tuned by signals from a multitude of immune receptors as well as conventional proteins such as integrins and nuclear receptors. Consequently, B cells significantly alter the network of signal transducers as well as transcription factors, thereby re-shaping their epigenome and transcriptome to instruct their activation, migration, proliferation, differentiation, and survival, particularly in the germinal center (GC) microenvironment. New insights have also been generated to understand how dysregulation of B cell responses leads to autoimmunity.","journal":"Frontiers in Immunology","year":2021,"id":215622,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":484605,"name":"Mark Boothby","orcid":"0000-0003-2593-8276","position":1,"is_corresponding":false},{"id":415573,"name":"Jayanta Chaudhuri","orcid":"0000-0002-3838-0075","position":2,"is_corresponding":false},{"id":379113,"name":"Zhenming Xu","orcid":"0000-0002-5822-0570","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:52:55.971300Z","pmid":"34858441","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}