{"doi":"10.3389/fimmu.2021.790415","title":"Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide","abstract":"To face the continuous emergence of SARS-CoV-2 variants, broadly protective therapeutic antibodies are highly needed. We here focused on the fusion peptide (FP) region of the viral spike antigen since it is highly conserved among alpha- and betacoronaviruses. First, we found that coronavirus cross-reactive antibodies are commonly formed during infection, being omnipresent in sera from COVID-19 patients, in ~50% of pre-pandemic human sera (rich in antibodies against endemic human coronaviruses), and even in feline coronavirus-infected cats. Pepscan analyses demonstrated that a confined N-terminal region of the FP is strongly immunogenic across diverse coronaviruses. Peptide-purified human antibodies targeting this conserved FP epitope exhibited broad binding of alpha- and betacoronaviruses, besides weak and transient SARS-CoV-2 neutralizing activity. Being frequently elicited by coronavirus infection, these FP-binding antibodies might potentially exhibit Fc-mediated effector functions and influence the kinetics or severity of coronavirus infection and disease.","journal":"Frontiers in Immunology","year":2022,"id":268933,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":737360,"name":"Annelies Stevaert","orcid":"0000-0003-3316-2826","position":1,"is_corresponding":false},{"id":696263,"name":"Jiexiong Xie","orcid":"0000-0002-3374-6605","position":2,"is_corresponding":false},{"id":931654,"name":"Xiaolei Ren","orcid":"0009-0008-7316-2277","position":3,"is_corresponding":false},{"id":931655,"name":"Cyril Barbezange","orcid":"0000-0001-9606-2983","position":4,"is_corresponding":false},{"id":931141,"name":"Sam Noppen","orcid":"0000-0002-2831-5042","position":5,"is_corresponding":false},{"id":589993,"name":"Isabelle Desombere","orcid":"0000-0003-3521-7712","position":6,"is_corresponding":false},{"id":931656,"name":"Bruno Verhasselt","orcid":"0000-0002-4645-1144","position":7,"is_corresponding":false},{"id":931657,"name":"Peter Geldhof","orcid":"0000-0001-8222-2966","position":8,"is_corresponding":false},{"id":931658,"name":"Nick Vereecke","orcid":"0000-0001-5367-9756","position":9,"is_corresponding":false},{"id":931659,"name":"V. Stroobants","orcid":"0000-0002-7150-7015","position":10,"is_corresponding":false},{"id":931660,"name":"Da-Young Oh","orcid":"0000-0002-1694-2620","position":11,"is_corresponding":false},{"id":932251,"name":"Merijn Vanhee","orcid":null,"position":12,"is_corresponding":false},{"id":737355,"name":"Lieve Naesens","orcid":"0000-0001-9742-9302","position":13,"is_corresponding":false},{"id":931661,"name":"Hans Nauwynck","orcid":"0000-0001-5470-0713","position":14,"is_corresponding":false},{"id":931653,"name":"Nathalie Vanderheijden","orcid":"0000-0002-7899-1161","position":0,"is_corresponding":true}],"reference_count":75,"raw_metadata":null,"created_at":"2026-07-19T00:27:18.142851Z","pmid":"35069571","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}