{"doi":"10.3389/fimmu.2021.748679","title":"A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes","abstract":"To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse. This mouse is deficient of murine major histocompatibility complex class I and class II, the murine insulin genes, and expresses as transgenes the HLA-A*02:01 allele, the diabetes high-susceptibility HLA-DQ8A and B alleles, the human insulin gene, and the human co-stimulatory molecule B7.1 in insulin-secreting cells. It develops spontaneous T1D along with CD4 + and CD8 + T-cell responses to human preproinsulin epitopes. Most of the responses identified in these mice were validated in T1D patients. This model is amenable to characterization of hPPI-specific epitopes involved in T1D and to the identification of factors that may trigger autoimmune response to insulin-secreting cells in human T1D. It will allow evaluating peptide-based immunotherapy that may directly apply to T1D in human and complete preclinical model availability to address the issue of clinical heterogeneity of human disease.","journal":"Frontiers in Immunology","year":2021,"id":190375,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9215,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":755239,"name":"Sophie Guinoiseau","orcid":null,"position":1,"is_corresponding":false},{"id":754422,"name":"Alexis Gadault","orcid":"0000-0001-5188-1328","position":2,"is_corresponding":false},{"id":623116,"name":"Franck Letourneur","orcid":"0000-0001-9465-4774","position":3,"is_corresponding":false},{"id":754423,"name":"Patrick Nitschké","orcid":"0000-0002-2094-3298","position":4,"is_corresponding":false},{"id":755240,"name":"Marc Bras","orcid":null,"position":5,"is_corresponding":false},{"id":171316,"name":"Michel Vidaud","orcid":null,"position":6,"is_corresponding":false},{"id":292389,"name":"Pierre Charneau","orcid":"0000-0003-1184-5773","position":7,"is_corresponding":false},{"id":726972,"name":"Étienne Larger","orcid":"0000-0002-1017-1845","position":8,"is_corresponding":false},{"id":262802,"name":"Máikel L. Colli","orcid":"0000-0002-2200-4761","position":9,"is_corresponding":false},{"id":262820,"name":"Décio L. Eizirik","orcid":"0000-0003-2453-5889","position":10,"is_corresponding":false},{"id":754424,"name":"François A. Lemonnier","orcid":"0000-0002-6741-2742","position":11,"is_corresponding":false},{"id":557126,"name":"Christian Boîtard","orcid":"0000-0003-3985-9405","position":12,"is_corresponding":false},{"id":557123,"name":"Sandrine Luce","orcid":"0000-0002-9519-333X","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-18T23:49:26.966524Z","pmid":"34721418","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}