{"doi":"10.3389/fimmu.2021.737923","title":"Editorial: The Role of Nuclear Molecules in the Pathogenesis of Autoimmune Disease","abstract":"Nuclear molecules are a diverse set of macromolecules whose designation as nuclear derives from their location rather than chemistry or function. These molecules include DNA, RNA and proteins although, in general, nuclear molecules exist as complexes of proteins and nucleic acids inside the cell. The focus on the nucleus as a defining feature of these molecules, while clearly correct, may nevertheless underestimate the importance of the translocation events that nuclear molecules undergo to serve their function. Thus, while DNA, RNA and proteins are major chemical constituents of the nucleus, their location is neither uniform nor fixed. As a group, these molecules can all migrate around the cell and variably appear in the nucleus and cytoplasm. Furthermore, they can exit the cell to enter the blood where they can display powerful immunological activities, seemingly unrelated to their nuclear function, and can drive the pathogenesis of autoimmunity.","journal":"Frontiers in Immunology","year":2021,"id":221345,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":821363,"name":"Reinhard Voll","orcid":"0000-0002-5542-9133","position":1,"is_corresponding":false},{"id":615647,"name":"Edit I. Buzás","orcid":"0000-0002-3744-206X","position":2,"is_corresponding":false},{"id":392718,"name":"David S. Pisetsky","orcid":"0000-0002-3539-5351","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:53:55.215284Z","pmid":"34421932","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}