{"doi":"10.3389/fimmu.2021.729186","title":"A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis","abstract":"South Africa has the highest prevalence of HIV and tuberculosis (TB) co-infection globally. Recurrent TB, caused by relapse or reinfection, makes up the majority of TB cases in South Africa, and HIV infected individuals have a greater likelihood of developing recurrent TB. Given that TB remains a leading cause of death for HIV infected individuals, and correlates of TB recurrence protection/risk have yet to be defined, here we sought to understand the antibody associated mechanisms of recurrent TB by investigating the humoral response in a longitudinal cohort of HIV co-infected individuals previously treated for TB with and without recurrent disease during follow-up, in order to identify antibody correlates of protection between individuals who do not have recurrent TB and individuals who do. We used a high-throughput, “systems serology” approach to profile biophysical and functional characteristics of antibodies targeting antigens from Mycobacterium tuberculosis (Mtb) . Differences in antibody profiles were noted between individuals with and without recurrent TB, albeit these differences were largely observed close to the time of re-diagnosis. Individuals with recurrent TB had decreased Mtb -antigen specific IgG3 titers, but not other IgG subclasses or IgA, compared to control individuals. These data point to a potential role for Mtb -specific IgG3 responses as biomarkers or direct mediators of protective immunity against Mtb recurrence.","journal":"Frontiers in Immunology","year":2021,"id":176712,"datarank":0.7332715788254482,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.2696152108217008,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.2696152108217008,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":15,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9587,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01539005"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":663368,"name":"Deniz Cizmeci","orcid":"0000-0003-3231-7726","position":1,"is_corresponding":false},{"id":108386,"name":"Sally Shin","orcid":"0000-0002-9306-2264","position":2,"is_corresponding":false},{"id":453396,"name":"Leela Davies","orcid":"0000-0003-4780-0606","position":3,"is_corresponding":false},{"id":297928,"name":"Patricia S. Grace","orcid":"0000-0002-4604-0943","position":4,"is_corresponding":false},{"id":367024,"name":"Aida Sivro","orcid":"0000-0001-9215-5285","position":5,"is_corresponding":false},{"id":463290,"name":"Nonhlanhla Yende‐Zuma","orcid":"0000-0002-3708-8611","position":6,"is_corresponding":false},{"id":64607,"name":"Hendrik Streeck","orcid":"0000-0002-0335-6390","position":7,"is_corresponding":false},{"id":91624,"name":"Sarah M. Fortune","orcid":"0000-0001-7565-9975","position":8,"is_corresponding":false},{"id":19320,"name":"Douglas A. Lauffenburger","orcid":"0000-0002-0050-989X","position":9,"is_corresponding":false},{"id":252303,"name":"Kogieleum Naidoo","orcid":"0000-0002-8874-6661","position":10,"is_corresponding":false},{"id":106757,"name":"Galit Alter","orcid":"0000-0002-7680-9215","position":11,"is_corresponding":false},{"id":106724,"name":"Stephanie Fischinger","orcid":"0000-0003-2307-3379","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T23:47:23.605867Z","pmid":"34630406","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}