{"doi":"10.3389/fimmu.2021.687669","title":"The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells","abstract":"Regulatory T cells (Tregs) play a crucial role in preventing antitumor immune responses in cancer tissues. Cancer tissues produce large amounts of transforming growth factor beta (TGF-β), which promotes the generation of Foxp3 + Tregs from naïve CD4 + T cells in the local tumor microenvironment. TGF-β activates nuclear factor kappa B (NF-κB)/p300 and SMAD signaling, which increases the number of acetylated histones at the Foxp3 locus and induces Foxp3 gene expression. TGF-β also helps stabilize Foxp3 expression. The curcumin analog and antitumor agent, GO-Y030, prevented the TGF-β-induced generation of Tregs by preventing p300 from accelerating NF-κB-induced Foxp3 expression. Moreover, the addition of GO-Y030 resulted in a significant reduction in the number of acetylated histones at the Foxp3 promoter and at the conserved noncoding sequence 1 regions that are generated in response to TGF-β. In vivo tumor models demonstrated that GO-Y030-treatment prevented tumor growth and reduced the Foxp3 + Tregs population in tumor-infiltrating lymphocytes. Therefore, GO-Y030 exerts a potent anticancer effect by controlling Treg generation and stability.","journal":"Frontiers in Immunology","year":2021,"id":169365,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.947,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":700196,"name":"Shuhei Kobayashi","orcid":"0000-0002-1019-8669","position":1,"is_corresponding":false},{"id":700197,"name":"Hiroko Nakatsukasa","orcid":"0000-0001-7023-9920","position":2,"is_corresponding":false},{"id":700198,"name":"Yuki Moritoki","orcid":"0000-0003-2822-3751","position":3,"is_corresponding":false},{"id":700199,"name":"Daiki Taguchi","orcid":"0000-0003-3426-8251","position":4,"is_corresponding":false},{"id":700200,"name":"Yoichi Sunagawa","orcid":"0000-0002-4516-2308","position":5,"is_corresponding":false},{"id":700201,"name":"Tatsuya Morimoto","orcid":"0000-0002-7054-4447","position":6,"is_corresponding":false},{"id":701186,"name":"Atsuko Asao","orcid":null,"position":7,"is_corresponding":false},{"id":277457,"name":"Wenwen Jin","orcid":"0000-0001-7771-3058","position":8,"is_corresponding":false},{"id":700202,"name":"Yuji Owada","orcid":"0000-0002-5109-0531","position":9,"is_corresponding":false},{"id":506219,"name":"Naoto Ishii","orcid":"0000-0002-0549-8245","position":10,"is_corresponding":false},{"id":700203,"name":"Yoshiharu Iwabuchi","orcid":"0000-0002-0679-939X","position":11,"is_corresponding":false},{"id":700204,"name":"Akihiko Yoshimura","orcid":"0000-0001-5676-8949","position":12,"is_corresponding":false},{"id":497251,"name":"Wanjun Chen","orcid":"0000-0002-8398-4548","position":13,"is_corresponding":false},{"id":700205,"name":"Hiroyuki Shibata","orcid":"0000-0003-3581-3506","position":14,"is_corresponding":false},{"id":230163,"name":"Takashi Maruyama","orcid":"0000-0003-0820-3219","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-18T23:46:15.560174Z","pmid":"34248973","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}