{"doi":"10.3389/fimmu.2021.684657","title":"The Role of Regulatory T Cells in Pulmonary Arterial Hypertension","abstract":"Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4 + CD25 high FOXP3 + Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.","journal":"Frontiers in Immunology","year":2021,"id":157006,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":517338,"name":"Shirley Y. Jiang","orcid":"0000-0002-0159-9698","position":1,"is_corresponding":false},{"id":292031,"name":"Xinguo Jiang","orcid":"0000-0003-3266-9238","position":2,"is_corresponding":false},{"id":664024,"name":"Rasa Tamošiūnienė","orcid":null,"position":3,"is_corresponding":false},{"id":292032,"name":"Dong-Eon Kim","orcid":"0000-0002-1674-1263","position":4,"is_corresponding":false},{"id":293608,"name":"Torrey Guan","orcid":null,"position":5,"is_corresponding":false},{"id":664025,"name":"Siham Arsalane","orcid":null,"position":6,"is_corresponding":false},{"id":494255,"name":"Shravani Pasupneti","orcid":"0000-0002-7112-601X","position":7,"is_corresponding":false},{"id":362568,"name":"Norbert F. Voelkel","orcid":null,"position":8,"is_corresponding":false},{"id":285543,"name":"Qizhi Tang","orcid":"0000-0001-7313-3574","position":9,"is_corresponding":false},{"id":292033,"name":"Mark R. Nicolls","orcid":"0000-0001-9473-7422","position":10,"is_corresponding":false},{"id":292030,"name":"Wen Tian","orcid":"0000-0002-0569-318X","position":0,"is_corresponding":true}],"reference_count":114,"raw_metadata":null,"created_at":"2026-07-18T23:44:17.471040Z","pmid":"34489935","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}