{"doi":"10.3389/fimmu.2021.654190","title":"Skin Resident Memory T Cells May Play Critical Role in Delayed-Type Drug Hypersensitivity Reactions","abstract":"Delayed-type drug hypersensitivity reactions (dtDHR) are immune-mediated reactions with skin and visceral manifestations ranging from mild to severe. Clinical care is negatively impacted by a limited understanding of disease pathogenesis. Though T cells are believed to orchestrate disease, the type of T cell and the location and mechanism of T cell activation remain unknown. Resident memory T cells (T RM ) are a unique T cell population potentially well situated to act as key mediators in disease pathogenesis, but significant obstacles to defining, identifying, and testing T RM in dtDHR preclude definitive conclusions at this time. Deeper mechanistic interrogation to address these unanswered questions is necessary, as involvement of T RM in disease has significant implications for prediction, diagnosis, and treatment of disease.","journal":"Frontiers in Immunology","year":2021,"id":170267,"datarank":1.0105685345882875,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.5054741600903164,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.5054741600903164,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":27,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9604,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":702448,"name":"Pranali Shah","orcid":"0000-0003-4653-0253","position":1,"is_corresponding":false},{"id":292493,"name":"Sherrie J. Divito","orcid":"0000-0002-9148-8691","position":2,"is_corresponding":false},{"id":646483,"name":"Elisa M. Schunkert","orcid":"0000-0002-4388-8420","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:19.728805Z","pmid":"34497600","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}