{"doi":"10.3389/fimmu.2021.615102","title":"Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients","abstract":"The re-emergence of Zika virus (ZIKV) caused widespread infections that were linked to Guillain-Barré syndrome in adults and congenital malformation in fetuses, and epidemiological data suggest that ZIKV infection can induce protective antibody responses. A more detailed understanding of anti-ZIKV antibody responses may lead to enhanced antibody discovery and improved vaccine designs against ZIKV and related flaviviruses. Here, we applied recently-invented library-scale antibody screening technologies to determine comprehensive functional molecular and genetic profiles of naturally elicited human anti-ZIKV antibodies in three convalescent individuals. We leveraged natively paired antibody yeast display and NGS to predict antibody cross-reactivities and coarse-grain antibody affinities, to perform in-depth immune profiling of IgM, IgG, and IgA antibody repertoires in peripheral blood, and to reveal virus maturation state-dependent antibody interactions. Repertoire-scale comparison of ZIKV VLP-specific and non-specific antibodies in the same individuals also showed that mean antibody somatic hypermutation levels were substantially influenced by donor-intrinsic characteristics. These data provide insights into antiviral antibody responses to ZIKV disease and outline systems-level strategies to track human antibody immune responses to emergent viral infections.","journal":"Frontiers in Immunology","year":2021,"id":173174,"datarank":0.48283137373023016,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.0,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":710310,"name":"Morgan R. Timm","orcid":"0000-0002-2947-9508","position":1,"is_corresponding":false},{"id":302419,"name":"Bharat Madan","orcid":"0000-0002-7376-9991","position":2,"is_corresponding":false},{"id":694074,"name":"Katherine E. Burgomaster","orcid":"0000-0002-5524-2467","position":3,"is_corresponding":false},{"id":437338,"name":"Kimberly A. Dowd","orcid":"0000-0003-3641-6852","position":4,"is_corresponding":false},{"id":472080,"name":"Erica Normandin","orcid":"0000-0002-4996-6442","position":5,"is_corresponding":false},{"id":236781,"name":"Matías Gutiérrez-González","orcid":"0000-0002-9729-6850","position":6,"is_corresponding":false},{"id":710311,"name":"Joseph M. Pennington","orcid":"0000-0002-9947-9028","position":7,"is_corresponding":false},{"id":302420,"name":"Matheus Oliveira de Souza","orcid":"0000-0003-0357-1995","position":8,"is_corresponding":false},{"id":619541,"name":"Amy R. Henry","orcid":null,"position":9,"is_corresponding":false},{"id":624395,"name":"Farida Laboune","orcid":null,"position":10,"is_corresponding":false},{"id":105588,"name":"Lingshu Wang","orcid":"0000-0002-8404-4910","position":11,"is_corresponding":false},{"id":280561,"name":"David R. Ambrozak","orcid":"0000-0003-1038-7328","position":12,"is_corresponding":false},{"id":622890,"name":"Ingelise J. Gordon","orcid":"0000-0001-6584-1589","position":13,"is_corresponding":false},{"id":277153,"name":"Daniel C. Douek","orcid":"0000-0001-5575-8634","position":14,"is_corresponding":false},{"id":218090,"name":"Julie E. Ledgerwood","orcid":"0000-0002-2047-6052","position":15,"is_corresponding":false},{"id":87311,"name":"Barney S. Graham","orcid":"0000-0001-8112-0853","position":16,"is_corresponding":false},{"id":554446,"name":"Leda R. Castilho","orcid":"0000-0002-5904-410X","position":17,"is_corresponding":false},{"id":106870,"name":"Theodore C. Pierson","orcid":"0000-0002-3795-4348","position":18,"is_corresponding":false},{"id":105614,"name":"John R. Mascola","orcid":"0000-0002-5293-4695","position":19,"is_corresponding":false},{"id":108827,"name":"Brandon J. DeKosky","orcid":"0000-0001-6406-0836","position":20,"is_corresponding":false},{"id":302417,"name":"Ahmed S. Fahad","orcid":"0000-0002-5088-9333","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:45.768135Z","pmid":"33732238","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}