{"doi":"10.3389/fimmu.2020.596772","title":"IL-2-Agonist-Induced IFN-γ Exacerbates Systemic Anaphylaxis in Food Allergen-Sensitized Mice","abstract":"Food allergies are common, costly and potentially life-threatening disorders. They are driven by Th2, but inhibited by Th1 reactions. There is also evidence indicating that IL-2 agonist treatment inhibits allergic sensitization through expansion of regulatory T cells. Here, we tested the impact of an IL-2 agonist in a novel model for food allergy to hen´s egg in mice sensitized without artificial adjuvants. Prophylactic IL-2 agonist treatment expanded Treg populations and inhibited allergen-specific sensitization. However, IL-2 agonist treatment of already sensitized mice increased mast cell responses and allergic anaphylaxis upon allergen re-challenge. These effects depended on allergen-specific IgE and were mediated through IFN-γ, as shown by IgE transfer and blockade of IFN-γ with monoclonal antibodies. These results suggest that although shifting the allergic reaction toward a Treg/Th1 response inhibits allergic sensitization, the prototypic Th1 cytokine IFN-γ promotes mast cell activation and allergen-induced anaphylaxis in individuals that are already IgE-sensitized. Hence, while a Th1 response can prevent the development of food allergy, IFN-γ has the ability to exacerbate already established food allergy.","journal":"Frontiers in Immunology","year":2020,"id":73109,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":385085,"name":"Christina N. Rau","orcid":"0000-0001-8825-1821","position":1,"is_corresponding":false},{"id":386376,"name":"Christopher C. Udoye","orcid":null,"position":2,"is_corresponding":false},{"id":386377,"name":"Mohab Ragab","orcid":null,"position":3,"is_corresponding":false},{"id":385086,"name":"Rabia Ülkü Korkmaz","orcid":"0000-0002-2566-5346","position":4,"is_corresponding":false},{"id":386378,"name":"Sara Comdühr","orcid":null,"position":5,"is_corresponding":false},{"id":385087,"name":"Ann‐Katrin Clauder","orcid":"0000-0002-2926-4056","position":6,"is_corresponding":false},{"id":386379,"name":"Timo Lindemann","orcid":null,"position":7,"is_corresponding":false},{"id":386380,"name":"Britta Frehse","orcid":null,"position":8,"is_corresponding":false},{"id":386381,"name":"Katharina Hofmann","orcid":null,"position":9,"is_corresponding":false},{"id":385088,"name":"Larissa N. Almeida","orcid":"0000-0003-2974-433X","position":10,"is_corresponding":false},{"id":385089,"name":"Yves Laumonnier","orcid":"0000-0001-9603-3269","position":11,"is_corresponding":false},{"id":386382,"name":"Asmaa El Beidaq","orcid":null,"position":12,"is_corresponding":false},{"id":385090,"name":"Fred D. Finkelman","orcid":"0000-0002-1815-1902","position":13,"is_corresponding":false},{"id":385091,"name":"Rudolf A. Manz","orcid":"0000-0003-1263-7693","position":14,"is_corresponding":false},{"id":386375,"name":"Christopher W.M. Link","orcid":null,"position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-18T21:45:32.034078Z","pmid":"33362780","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}