{"doi":"10.3389/fimmu.2020.583338","title":"Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism","abstract":"We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4 + T cells from DBA/2 mice into (C57BL/6 × DBA/2)F 1 (BDF1) mice. Although the protective effects were ascribed to the induction of adaptive CD4 + and CD8 + T regulatory cells, the results suggested that another population of immune cells could be involved. Here we report that NK cells critically contribute to the protection from lupus-like disease conferred by NPs to BDF1 mice, and that this effect is TGF-β-dependent.","journal":"Frontiers in Immunology","year":2020,"id":80776,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":418339,"name":"Aijing Liu","orcid":"0000-0001-9714-7620","position":1,"is_corresponding":false},{"id":105778,"name":"Sean Bickerton","orcid":"0000-0002-3514-0308","position":2,"is_corresponding":false},{"id":418340,"name":"Giuseppe Castaldo","orcid":"0000-0002-4036-0874","position":3,"is_corresponding":false},{"id":225194,"name":"Giuseppe Matarese","orcid":"0000-0001-9429-0616","position":4,"is_corresponding":false},{"id":299632,"name":"Tarek M. Fahmy","orcid":"0000-0001-8740-4179","position":5,"is_corresponding":false},{"id":418341,"name":"Antonio La Cava","orcid":"0000-0002-8839-0933","position":6,"is_corresponding":false},{"id":419226,"name":"David A. Horwitz","orcid":null,"position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-18T21:51:58.988919Z","pmid":"33391260","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}