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More sensitive biomarkers to monitor the immune response, as well as combining multiple immunotherapy strategies, may accelerate clinical progress and enable development of effective and safe treatments for glioma patients.</jats:p>","journal":"Frontiers in Immunology","year":2020,"id":616085,"datarank":0.7555428903620446,"base_score":5.0369526024136295,"endowment":5.0369526024136295,"self_citation_contribution":0.7555428903620446,"citation_network_contribution":0.0,"self_endowment_contribution":0.7555428903620446,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":153,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1588230,"name":"Baohui Liu","orcid":null,"position":1,"is_corresponding":false},{"id":416511,"name":"Qian Sun","orcid":"0000-0002-0297-5376","position":2,"is_corresponding":false},{"id":1588232,"name":"Xiaoxing Xiong","orcid":null,"position":3,"is_corresponding":false},{"id":461784,"name":"Qianxue Chen","orcid":"0000-0002-9413-1030","position":4,"is_corresponding":false},{"id":1588228,"name":"Yangzhi Qi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Immune Checkpoint Targeted Therapy in Glioma: Status and Hopes","abstract":"<jats:p>Glioma is the most malignant primary tumor of the central nervous system and is characterized by an extremely low overall survival. Recent breakthroughs in cancer therapy using immune checkpoint blockade have attracted significant attention. However, despite representing the most promising (immunotherapy) treatment for cancer, the clinical application of immune checkpoint blockade in glioma patients remains challenging due to the “cold phenotype” of glioma and multiple factors inducing resistance, both intrinsic and acquired. Therefore, comprehensive understanding of the tumor microenvironment and the unique immunological status of the brain will be critical for the application of glioma immunotherapy. More sensitive biomarkers to monitor the immune response, as well as combining multiple immunotherapy strategies, may accelerate clinical progress and enable development of effective and safe treatments for glioma patients.</jats:p>","is_dataset_classified":null,"base_score":5.0369526024136295,"endowment":5.0369526024136295,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33329549","pmcid":"PMC7729019","openalex_id":"https://openalex.org/W3107038423","authors":[],"funders":[],"total_grants":0,"fwci":12.2392,"citation_percentile":0.99218837,"influential_citations":0,"citation_trend":[{"year":2021,"count":16},{"year":2022,"count":27},{"year":2023,"count":57},{"year":2024,"count":35},{"year":2025,"count":15},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.578877/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.578877/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.578877/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fimmu.2020.578877","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33329549","host_type":"repository"},{"url":"https://doaj.org/article/a5f958b955904e79892494a1f7fdc054","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7729019","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7729019","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7729019?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Glioma Diagnosis and Treatment","Cancer Immunotherapy and Biomarkers","Immune cells in cancer"],"mesh_terms":["Immune Checkpoint Inhibitors","Animals","Brain Neoplasms","Glioma","Humans","Signal Transduction","Treatment Outcome","Molecular Targeted Therapy","Tumor Microenvironment"],"keywords":["Glioma","Immune checkpoint","Medicine","Immune system","Immunotherapy","Cancer research","Immunology","Immune Checkpoint Blockade","Glioma Microenvironment","Immunotherapy Resistance","Immune-Response Monitoring Biomarker","Brain Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T21:54:47.611488Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}