{"doi":"10.3389/fimmu.2020.00470","title":"A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments","abstract":"1 Abstract The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendritic cells that we find express Tcf7. We identified a 1kb regulatory element crucial for the initiation of Tcf7 expression in T cells and innate lymphoid cells, but dispensable for Tcf7 expression in Tcf7-expressing dendritic cells. Within this region, we identified a Notch binding site important for the initiation of Tcf7 expression in T cells but not in innate lymphoid cells. Our work establishes that the same regulatory element is used by distinct transcriptional controllers to initiate Tcf7 expression in T cells and ILCs.","journal":"Frontiers in Immunology","year":2020,"id":94661,"datarank":0.5456379239589579,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.0,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471417,"name":"Devin Kenney","orcid":"0000-0002-8758-1930","position":1,"is_corresponding":false},{"id":471418,"name":"Yueqiang Wang","orcid":"0000-0002-9246-0877","position":2,"is_corresponding":false},{"id":366403,"name":"Yi Ding","orcid":"0000-0002-1958-8524","position":3,"is_corresponding":false},{"id":471419,"name":"Yongge Zhao","orcid":"0000-0003-4466-2391","position":4,"is_corresponding":false},{"id":262758,"name":"Parirokh Awasthi","orcid":"0000-0002-5831-9781","position":5,"is_corresponding":false},{"id":471420,"name":"Avinash Bhandoola","orcid":"0000-0002-4657-8372","position":6,"is_corresponding":false},{"id":471416,"name":"Christelle Harly","orcid":"0000-0002-8045-9166","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T22:33:00.770265Z","pmid":"32265924","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}