{"doi":"10.3389/fimmu.2020.00144","title":"Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation","abstract":null,"journal":"Frontiers in Immunology","year":2020,"id":591008,"datarank":1.5283531228570841,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.93566656506987,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.93566656506987,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":47,"citers_with_citation_signal":40,"citers_with_endowment":40,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1512065,"name":"Florent Bataille","orcid":null,"position":1,"is_corresponding":false},{"id":1512066,"name":"Isabelle Maillet","orcid":null,"position":2,"is_corresponding":false},{"id":1512067,"name":"Louis Fauconnier","orcid":null,"position":3,"is_corresponding":false},{"id":309063,"name":"Cyril Colas","orcid":"0000-0003-1651-6813","position":4,"is_corresponding":false},{"id":1119,"name":"Harry Sokol","orcid":"0000-0002-2914-1822","position":5,"is_corresponding":false},{"id":1512068,"name":"Marjolène Straube","orcid":null,"position":6,"is_corresponding":false},{"id":1512069,"name":"Aurélie Couturier-Maillard","orcid":null,"position":7,"is_corresponding":false},{"id":308967,"name":"Laure Dumoutier","orcid":"0000-0002-6645-684X","position":8,"is_corresponding":false},{"id":1512070,"name":"Jacques van Snick","orcid":null,"position":9,"is_corresponding":false},{"id":1512071,"name":"Valérie F. Quesniaux","orcid":null,"position":10,"is_corresponding":false},{"id":1512072,"name":"Dieudonnée Togbe","orcid":null,"position":11,"is_corresponding":false},{"id":91576,"name":"Bernhard Ryffel","orcid":"0000-0003-2897-8230","position":12,"is_corresponding":false},{"id":1512064,"name":"Chloé Michaudel","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation","abstract":"Airborne ozone exposure causes severe lung injury and inflammation. Aryl hydrocarbon Receptor (Lee et al.), activated in pollutant-induced inflammation, is critical for cytokine production, especially IL-22 and IL-17A. The role of AhR in ozone induced lung inflammation is unknown. We report here that chronic ozone exposure activates AhR with increased tryptophan and lipoxin A4 production in mice. AhR-/- mice show increased lung inflammation, airways hyperresponsiveness and tissue remodelling with an increased recruitment of IL-17A and IL-22-expressing cells in comparison to control mice. IL-17A- and IL-22-neutralizing antibodies attenuate lung inflammation in AhR-/- and control mice. Enhanced lung inflammation and recruitment of ILC3, ILC2 and T cells were observed after T cell-specific AhR depletion using the AhRCD4cre deficient mice. Altogether, the data demonstrate that ozone activates AhR, which control lung inflammation, airway hyperresponsiveness and tissue remodelling via the reduction of IL-22 expression.","is_dataset_classified":null,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32161582","pmcid":"PMC7053361","openalex_id":"https://openalex.org/W3007206531","authors":[],"funders":[],"total_grants":0,"fwci":3.0204,"citation_percentile":0.92249618,"influential_citations":0,"citation_trend":[{"year":2020,"count":4},{"year":2021,"count":9},{"year":2022,"count":12},{"year":2023,"count":8},{"year":2024,"count":9},{"year":2025,"count":6},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.3389/fimmu.2020.00144","host_type":"journal"},{"url":"https://doi.org/10.3389/fimmu.2020.00144","host_type":"publisher"},{"url":"https://www.frontiersin.org/article/10.3389/fimmu.2020.00144/full","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32161582","host_type":"repository"},{"url":"https://hal.science/hal-03008360","host_type":"repository"},{"url":"http://hdl.handle.net/2078.1/230993","host_type":"repository"},{"url":"https://doaj.org/article/50adb8baaf7f4721927e5fc3536627e5","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7053361","host_type":"repository"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.00144/pdf","host_type":"Unpaywall"},{"url":"https://europepmc.org/articles/PMC7053361","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7053361?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Air Quality and Health Impacts","IL-33, ST2, and ILC Pathways","Medical and Biological Ozone Research","Animals","Antibodies, Neutralizing","Basic Helix-Loop-Helix Proteins","CD4-Positive T-Lymphocytes","Interleukin-17","Interleukins","Lipoxins","Lung Injury","Mice","Mice, Inbred C57BL","Mice, Knockout","Ozone","Pneumonia","Receptors, Aryl Hydrocarbon","Receptors, Interleukin-17","Respiratory Hypersensitivity","Tryptophan","Interleukin-22"],"mesh_terms":["Interleukin-22","Animals","Interleukins","Mice, Inbred C57BL","Ozone","Pneumonia","Respiratory Hypersensitivity","Tryptophan","CD4-Positive T-Lymphocytes","Receptors, Aryl Hydrocarbon","Mice, Knockout","Interleukin-17","Lipoxins","Mice","Basic Helix-Loop-Helix Transcription Factors","Basic Helix-Loop-Helix Proteins","Receptors, Interleukin-17","Lung Injury","Antibodies, Neutralizing"],"keywords":["Aryl hydrocarbon receptor","Inflammation","Interleukin 22","Immunology","Lung","Cytokine","Medicine","Interleukin","Chemistry","Internal medicine","Biochemistry","Ozone","T cells","Il-17","AhR","Il-22","Ilc3"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T13:38:49.144682Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}