{"doi":"10.3389/fimmu.2020.00042","title":"Regulation of γδ T Cell Effector Diversification in the Thymus","abstract":"γδ T cells are the first T cell lineage to develop in the thymus and take up residence in a wide variety of tissues where they can provide fast, innate-like sources of effector cytokines for barrier defense. In contrast to conventional αβ T cells that egress the thymus as naïve cells, γδ T cells can be programmed for effector function during development in the thymus. Understanding the molecular mechanisms that determine γδ T cell effector fate is of great interest due to the wide-spread tissue distribution of γδ T cells and their roles in pathogen clearance, immunosurveillance, cancer, and autoimmune diseases. In this review, we will integrate the current understanding of the role of the T cell receptor, environmental signals, and transcription factor networks in controlling mouse innate-like γδ T cell effector commitment.","journal":"Frontiers in Immunology","year":2020,"id":54897,"datarank":2.6969069570416235,"base_score":4.605170185988092,"endowment":4.605170185988092,"self_citation_contribution":0.6907755278982138,"citation_network_contribution":2.0061314291434096,"self_endowment_contribution":0.6907755278982138,"citer_contribution":2.0061314291434096,"corpus_percentile":null,"corpus_rank":null,"citation_count":99,"citer_count":94,"citers_with_citation_signal":77,"citers_with_endowment":77,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9491,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":282773,"name":"Maria Ciofani","orcid":"0000-0001-6472-5260","position":1,"is_corresponding":false},{"id":282772,"name":"Morgan E. Parker","orcid":"0000-0003-2610-8530","position":0,"is_corresponding":true}],"reference_count":115,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:04:14.743014Z","pmid":"32038664","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}