{"doi":"10.3389/fimmu.2018.02694","title":"Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma","abstract":null,"journal":"Frontiers in Immunology","year":2018,"id":602776,"datarank":0.6190701577567639,"base_score":4.127134385045092,"endowment":4.127134385045092,"self_citation_contribution":0.6190701577567639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6190701577567639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1546087,"name":"Pedram Shafiei Jahani","orcid":null,"position":1,"is_corresponding":false},{"id":241529,"name":"Omid Akbari","orcid":"0000-0002-4359-9725","position":2,"is_corresponding":false},{"id":241528,"name":"Benjamin P. Hurrell","orcid":"0000-0001-7753-2927","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Social Networking of Group Two Innate Lymphoid Cells in Allergy and Asthma","abstract":"Allergic diseases including asthma, chronic rhinosinusitis, and atopic dermatitis are common conditions worldwide. While type 2 immune responses induced by T-cells significantly cause allergic inflammation, the recently identified group two innate lymphoid cells (ILC2s) are emerging as critical players in the development of allergy. Upon allergen exposure, ILC2s are rapidly activated by cytokines released by epithelial cells. Activated ILC2s release various effector cytokines altogether contributing to the pathogenesis of allergy and can even cause inflammation in the absence of T-cells, as observed in asthma. Although the factors inducing ILC2 activation have been identified, evidence suggests that multiple factors can enhance or repress ILC2 proliferation, trafficking, or secretion of effector cytokines upon allergic inflammation. In this review, we discuss the recent findings that influence ILC2 activation and the resulting effects on the pathogenesis of allergy. A better understanding of how ILC2s are modulated will open the door to the development of new therapeutic strategies against allergic diseases.","is_dataset_classified":null,"base_score":4.127134385045092,"endowment":4.127134385045092,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30524437","pmcid":"PMC6256740","openalex_id":"https://openalex.org/W2900916646","authors":[],"funders":[{"funder_name":"NIEHS NIH HHS","grant_id":"R01 ES025786","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"P30 ES007048","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"R01 ES021801","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI109059","title":null},{"funder_name":"NIEHS NIH HHS","grant_id":"R21 ES024707","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R21ES024707-01","title":"Air pollution, immune modulation of adipose tissue and type-2 diabetes risk factors"},{"funder_name":"National Institutes of Health","grant_id":"5R01ES021801-04","title":"INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMA"},{"funder_name":"Swiss National Science Foundation","grant_id":"181286","title":"Modulation of ILC2 trafficking and effector functions in ILC2-driven airway hyperreactivity"},{"funder_name":"National Institutes of Health","grant_id":"1R21AI109059-01A1","title":"The function of CRAC channels in airway inflammation"},{"funder_name":"National Institutes of Health","grant_id":"1R01ES025786-01","title":"Genetic and Environmental Determinants of Asthma Endophenotypes"}],"total_grants":10,"fwci":3.2959,"citation_percentile":0.92990899,"influential_citations":0,"citation_trend":[{"year":2019,"count":6},{"year":2020,"count":19},{"year":2021,"count":14},{"year":2022,"count":8},{"year":2023,"count":3},{"year":2024,"count":6},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.02694/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.02694/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/article/10.3389/fimmu.2018.02694/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fimmu.2018.02694","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30524437","host_type":"repository"},{"url":"https://doaj.org/article/6574d13523e743daad4a09bae0fc2085","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6256740","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6256740","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6256740","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6256740?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3389/fimmu.2018.02694","host_type":""},{"url":"https://dx.doi.org/10.3389/fimmu.2018.02694","host_type":""}],"fields_of_study":["IL-33, ST2, and ILC Pathways","Eosinophilic Esophagitis","Asthma and respiratory diseases","03 medical and health sciences","0302 clinical medicine","Asthma","Cell Movement","Cell Proliferation","Immunity, Innate","Inflammation","T-Lymphocytes"],"mesh_terms":["Asthma","Cell Movement","Immunity, Innate","Inflammation","T-Lymphocytes","Cell Proliferation"],"keywords":["Innate lymphoid cell","Immunology","Allergy","Asthma","Pathogenesis","Allergic inflammation","Inflammation","Medicine","Atopic dermatitis","Effector","Immune system","Innate immune system","Inhibition","Activation","Allergic disease","Ilc2","T-Lymphocytes","RC581-607","Immunity, Innate","Cell Movement","Immunologic diseases. 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