{"doi":"10.3389/fimmu.2018.00374","title":"Modulation of Gut Microbiota: A Novel Paradigm of Enhancing the Efficacy of Programmed Death-1 and Programmed Death Ligand-1 Blockade Therapy","abstract":null,"journal":"Frontiers in Immunology","year":2018,"id":591456,"datarank":2.8099412295116863,"base_score":4.276666119016055,"endowment":4.276666119016055,"self_citation_contribution":0.6414999178524083,"citation_network_contribution":2.168441311659278,"self_endowment_contribution":0.6414999178524083,"citer_contribution":2.168441311659278,"corpus_percentile":null,"corpus_rank":null,"citation_count":71,"citer_count":69,"citers_with_citation_signal":64,"citers_with_endowment":64,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1513296,"name":"Rena Ma","orcid":null,"position":1,"is_corresponding":false},{"id":911651,"name":"Fang Liu","orcid":"0000-0002-0046-8434","position":2,"is_corresponding":false},{"id":1513297,"name":"Seul A. 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In this review, we summarize the recent studies on the effects of gut microbiota on PD-1 and PD-L1 blockade and discuss the new perspectives on improving efficacy of PD-1 and PD-L1 blockade therapy in cancer treatment through modulating gut microbiota. We also discuss the possibility that chronic infections or inflammation may impact on PD-1 and PD-L1 blockade therapy.","is_dataset_classified":null,"base_score":4.276666119016055,"endowment":4.276666119016055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29556232","pmcid":"PMC5845387","openalex_id":"https://openalex.org/W2794323030","authors":[],"funders":[{"funder_name":"University of New South Wales","grant_id":"PS46772","title":null}],"total_grants":1,"fwci":2.7189,"citation_percentile":0.91401245,"influential_citations":0,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":9},{"year":2020,"count":12},{"year":2021,"count":9},{"year":2022,"count":11},{"year":2023,"count":6},{"year":2024,"count":10},{"year":2025,"count":8},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00374/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.00374/pdf","host_type":"publisher"},{"url":"http://journal.frontiersin.org/article/10.3389/fimmu.2018.00374/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fimmu.2018.00374","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29556232","host_type":"repository"},{"url":"https://doaj.org/article/2853eab565f5440590c95772d3862673","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5845387","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5845387","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5845387?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Gut microbiota and health","Cancer Immunotherapy and Biomarkers","Clostridium difficile and Clostridium perfringens research","Animals","Antibodies, Monoclonal","B7-H1 Antigen","Gastrointestinal Microbiome","Humans","Immunotherapy","Infections","Inflammation","Neoplasms","Programmed Cell Death 1 Receptor"],"mesh_terms":["Gastrointestinal Microbiome","Animals","Antibodies, Monoclonal","Humans","Immunotherapy","Infections","Inflammation","Neoplasms","B7-H1 Antigen","Programmed Cell Death 1 Receptor"],"keywords":["Blockade","Immunotherapy","Medicine","Immune checkpoint","Cancer","PD-L1","Cancer therapy","Gut flora","Immunology","Receptor","Internal medicine","efficacy","Cancer Immunotherapy","Gut Microbiota","Programmed Death 1","Programmed Death Ligand 1"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T16:44:37.712350Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}