{"doi":"10.3389/fimmu.2017.01930","title":"Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa","abstract":null,"journal":"Frontiers in Immunology","year":2018,"id":616901,"datarank":1.7059142336693385,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":1.107566626684697,"self_endowment_contribution":0.5983476069846413,"citer_contribution":1.107566626684697,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":44,"citers_with_citation_signal":37,"citers_with_endowment":37,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":905966,"name":"Tobias Goldmann","orcid":"0000-0001-9754-9144","position":1,"is_corresponding":false},{"id":1590671,"name":"Mirja Koch","orcid":null,"position":2,"is_corresponding":false},{"id":1366817,"name":"Lukas Amann","orcid":"0000-0002-8363-373X","position":3,"is_corresponding":false},{"id":1590674,"name":"Christian Schön","orcid":null,"position":4,"is_corresponding":false},{"id":1590676,"name":"Michael Bonin","orcid":null,"position":5,"is_corresponding":false},{"id":1161834,"name":"Shengru Pang","orcid":null,"position":6,"is_corresponding":false},{"id":87170,"name":"Marco Prinz","orcid":"0000-0002-0349-1955","position":7,"is_corresponding":false},{"id":1590679,"name":"Michael Burnet","orcid":null,"position":8,"is_corresponding":false},{"id":1590681,"name":"Johanna E. Wagner","orcid":null,"position":9,"is_corresponding":false},{"id":68326,"name":"Martin Biel","orcid":"0000-0002-9974-3052","position":10,"is_corresponding":false},{"id":98780,"name":"Stylianos Michalakis","orcid":"0000-0001-5092-9238","position":11,"is_corresponding":false},{"id":1590670,"name":"Thomas Blank","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa","abstract":"Retinitis pigmentosa (RP) denotes a family of inherited blinding eye diseases characterized by progressive degeneration of rod and cone photoreceptors in the retina. In most cases a rod-specific genetic defect results in early functional loss and degeneration of rods, which is followed by degeneration of cones and loss of daylight vision at later stages. Microglial cells, the immune cells of the central nervous system (CNS), are activated in retinas of RP patients and in several RP mouse models. However, it is still a matter of debate whether activated microglial cells may be responsible for the amplification of the typical degenerative processes. Here, we used Cngb1-/- mice, which represent a slow degenerative mouse model of RP, to investigate the extent of microglia activation in retinal degeneration. With a combination of FACS analysis, immunohistochemistry and gene expression analysis we established that microglia in the Cngb1-/- retina were already activated in an early, pre-degenerative stage of the disease. The evidence available so far suggests that early retinal microglia activation represents a first step in RP, which might initiate or accelerate photoreceptor degeneration.","is_dataset_classified":null,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29354133","pmcid":"PMC5760536","openalex_id":"https://openalex.org/W2782251840","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"EXC114","title":null},{"funder_name":"Seventh Framework Programme","grant_id":"No. 304884","title":null},{"funder_name":"European Commission","grant_id":"304884","title":"Prolonged inhibition of semaphorine3a pathway via a bio-degradable implant towards a better therapy for visual sensory impairments"},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":4,"fwci":1.7029,"citation_percentile":0.84206113,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2019,"count":4},{"year":2020,"count":6},{"year":2021,"count":5},{"year":2022,"count":7},{"year":2023,"count":7},{"year":2024,"count":11},{"year":2025,"count":8},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.01930/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2017.01930/pdf","host_type":"publisher"},{"url":"http://journal.frontiersin.org/article/10.3389/fimmu.2017.01930/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fimmu.2017.01930","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29354133","host_type":"repository"},{"url":"https://doaj.org/article/c6f186a36aae4f7cbde5926888213504","host_type":"repository"},{"url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-68175-3","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5760536","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5760536","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5760536?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3389/fimmu.2017.01930","host_type":""},{"url":"https://dx.doi.org/10.3389/fimmu.2017.01930","host_type":""},{"url":"https://epub.ub.uni-muenchen.de/68175/","host_type":""},{"url":"https://doi.org/https://doi.org/10.3389/fimmu.2017.01930","host_type":""}],"fields_of_study":["Neuroinflammation and Neurodegeneration Mechanisms","Retinal Development and Disorders","Retinal Diseases and Treatments","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Retinitis pigmentosa","Microglia","Retinal degeneration","Retina","Degeneration (medical)","Biology","Macular degeneration","Neuroscience","Retinal","Pathology","Medicine","Immunology","Ophthalmology","Inflammation","innate immune response","Cyclic Nucleotide-gated Channel","610","Immunologic diseases. 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