{"doi":"10.3389/fimmu.2012.00286","title":"DAMP signaling in fungal infections and diseases","abstract":null,"journal":"Frontiers in Immunology","year":2012,"id":618289,"datarank":0.6284482113039639,"base_score":4.189654742026425,"endowment":4.189654742026425,"self_citation_contribution":0.6284482113039639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6284482113039639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":355369,"name":"Agostinho Carvalho","orcid":"0000-0001-8935-8030","position":1,"is_corresponding":false},{"id":1594934,"name":"Antonella Esposito","orcid":null,"position":2,"is_corresponding":false},{"id":1594935,"name":"Francesco Bistoni","orcid":null,"position":3,"is_corresponding":false},{"id":688133,"name":"Luigina Romani","orcid":"0000-0002-1356-525X","position":4,"is_corresponding":false},{"id":355368,"name":"Cristina Cunha","orcid":"0000-0002-6002-5782","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"DAMP signaling in fungal infections and diseases","abstract":"Fungal infections and diseases predominantly affect patients with deregulated immunity. Compelling experimental and clinical evidence indicate that severe fungal diseases belong to the spectrum of fungus-related inflammatory diseases. Some degree of inflammation is required for protection during the transitional response occurring temporally between the rapid innate and slower adaptive response. However, progressive inflammation worsens disease and ultimately prevents pathogen eradication. The challenge now is to elucidate cellular and molecular pathways distinguishing protective vs. pathogenic inflammation to fungi. In addition to fungal ligands of pattern recognition receptors (pathogen-associated molecular patterns, PAMPs), several host-encoded proteins, the damage-associated molecular patterns (DAMPs), are released during tissue injury and activate innate recognition receptors. DAMPs have been shown to regulate inflammation in fungal diseases. The DAMP/receptor for advanced glycation end-products axis integrated with the PAMP/Toll-like receptors axis in the generation of the inflammatory response in experimental and clinical fungal pneumonia. These emerging themes better accommodate fungal pathogenesis in the face of high-level inflammation seen in several clinical settings and point to DAMP targeting as a novel immunomodulatory strategy in fungal diseases.","is_dataset_classified":null,"base_score":4.189654742026425,"endowment":4.189654742026425,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22973279","pmcid":null,"openalex_id":"https://openalex.org/W2096097730","authors":[],"funders":[{"funder_name":"Fundação para a Ciência e a Tecnologia, I.P.","grant_id":"SFRH/BD/65962/2009","title":"SUSCEPTIBILITY TO FUNGAL INFECTIONS IN THE ALLOGENEIC STEM CELL TRANSPLANTATION SETTING: THE ROLE OF GENETIC VARIANTS IN DECTIN-1 AND TOLL-LIKE RECEPTOR SIGNALING PATHWAYS"},{"funder_name":"European Commission","grant_id":"260338","title":"Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices"},{"funder_name":"Fundação para a Ciência e a Tecnologia, I.P.","grant_id":"SFRH/BPD/46292/2008","title":"SUSCEPTIBILITY TO INFECTIOUS DISEASE IN HAEMATOPOIETIC STEM CELL TRANSPLANTATION: THE ROLE OF POLYMORPHISMS IN THE TOLL-LIKE RECEPTOR SIGNALLING PATHWAYS"}],"total_grants":3,"fwci":1.5117,"citation_percentile":0.81500655,"influential_citations":0,"citation_trend":[{"year":2013,"count":4},{"year":2014,"count":3},{"year":2015,"count":6},{"year":2016,"count":3},{"year":2017,"count":2},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":4},{"year":2021,"count":14},{"year":2022,"count":13},{"year":2023,"count":4},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2012.00286/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2012.00286/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3389/fimmu.2012.00286","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22973279","host_type":"repository"},{"url":"https://doaj.org/article/919f5f66536e445ea00c27bcc7e63a95","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3437516","host_type":"repository"},{"url":"http://hdl.handle.net/1822/23918","host_type":"repository"},{"url":"https://hdl.handle.net/1822/23918","host_type":"repository"},{"url":"http://dx.doi.org/10.3389/fimmu.2012.00286","host_type":""},{"url":"https://dx.doi.org/10.3389/fimmu.2012.00286","host_type":""}],"fields_of_study":["Neutrophil, Myeloperoxidase and Oxidative Mechanisms","Antifungal resistance and susceptibility","Studies on Chitinases and Chitosanases","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Damp","Inflammation","Pattern recognition receptor","Innate immune system","Immunology","Pathogen-associated molecular pattern","Biology","Pathogenesis","Receptor","Acquired immune system","Immunity","Immune system","DAMPs","PAMPs","immunoregulation","RC581-607","fungal diseases","Immunologic diseases. 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