{"doi":"10.3389/fimmu.2011.00077","title":"Exploiting Human Memory B Cell Heterogeneity for Improved Vaccine Efficacy","abstract":null,"journal":"Frontiers in Immunology","year":2011,"id":651074,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1697886,"name":"Carole J. Henry Dunand","orcid":null,"position":1,"is_corresponding":false},{"id":233144,"name":"Patrick C. Wilson","orcid":"0000-0002-3537-1245","position":2,"is_corresponding":false},{"id":638969,"name":"Noel T. Pauli","orcid":"0000-0002-0853-2429","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Exploiting Human Memory B Cell Heterogeneity for Improved Vaccine Efficacy","abstract":"The major goal in vaccination is establishment of long-term, prophylactic humoral memory to a pathogen. Two major components to long-lived humoral memory are plasma cells for the production of specific immunoglobulin and memory B cells that survey for their specific antigen in the periphery for later affinity maturation, proliferation, and differentiation. The study of human B cell memory has been aided by the discovery of a general marker for B cell memory, expression of CD27; however, new data suggests the existence of CD27⁻ memory B cells as well. These recently described non-canonical memory populations have increasingly pointed to the heterogeneity of the memory compartment. The novel B memory subsets in humans appear to have unique origins, localization, and functions compared to what was considered to be a \"classical\" memory B cell. In this article, we review the known B cell memory subsets, the establishment of B cell memory in vaccination and infection, and how understanding these newly described subsets can inform vaccine design and disease treatment.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22566866","pmcid":"PMC3342318","openalex_id":"https://openalex.org/W2096953003","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"U19 AI062629","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"T32 AI007090","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"RC4 AI092711","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U19 AI057266","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U19 AI082724","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U54 AI057158","title":null},{"funder_name":"National Institutes of Health","grant_id":"5U19AI062629-07","title":"Administration Core"},{"funder_name":"National Institutes of Health","grant_id":"2U54AI057158-06","title":"Live, recombinant newcastle disease virus-based vaccine against high pri pathoge"},{"funder_name":"National Institutes of Health","grant_id":"5T32AI007090-33","title":"Interdisciplinary Training Program in Immunology"},{"funder_name":"National Institutes of Health","grant_id":"5U19AI082724-02","title":"Administrative Core"},{"funder_name":"National Institutes of Health","grant_id":"2U19AI057266-06","title":"Clinical and Statistical"},{"funder_name":"National Institutes of Health","grant_id":"5U19AI082724-10","title":"University of Chicago Autoimmunity Center of Excellence"},{"funder_name":"National Institutes of Health","grant_id":"1RC4AI092711-01","title":"Prevention and therapy of Staphylococcus aureus infections"}],"total_grants":13,"fwci":0.799,"citation_percentile":0.70422627,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":4},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2011.00077/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fimmu.2011.00077/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3389/fimmu.2011.00077","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22566866","host_type":"repository"},{"url":"https://doaj.org/article/adc32919a5a34acbaca31538aab5243c","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3342318","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC3342318","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC3342318?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3389/fimmu.2011.00077","host_type":""},{"url":"https://dx.doi.org/10.3389/fimmu.2011.00077","host_type":""}],"fields_of_study":["T-cell and B-cell Immunology","Immunotherapy and Immune Responses","vaccines and immunoinformatics approaches","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":[],"keywords":["Memory B cell","Human memory","Immunological memory","Memory T cell","Immunology","B cell","Memory cell","Antibody","Biology","Naive B cell","Antigen","Neuroscience","Immune system","T cell","Immunity","Cognition","Antigen-presenting cell","Immunoglobulin","Vaccine","Influenza","anthrax","B Cell Subset","RC581-607","Immunologic diseases. 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