{"doi":"10.3389/fgene.2021.777076","title":"Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program","abstract":"SARS-CoV-2 has caused symptomatic COVID-19 and widespread death across the globe. We sought to determine genetic variants contributing to COVID-19 susceptibility and hospitalization in a large biobank linked to a national United States health system. We identified 19,168 (3.7%) lab-confirmed COVID-19 cases among Million Veteran Program participants between March 1, 2020, and February 2, 2021, including 11,778 Whites, 4,893 Blacks, and 2,497 Hispanics. A multi-population genome-wide association study (GWAS) for COVID-19 outcomes identified four independent genetic variants (rs8176719, rs73062389, rs60870724, and rs73910904) contributing to COVID-19 positivity, including one novel locus found exclusively among Hispanics. We replicated eight of nine previously reported genetic associations at an alpha of 0.05 in at least one population-specific or the multi-population meta-analysis for one of the four MVP COVID-19 outcomes. We used rs8176719 and three additional variants to accurately infer ABO blood types. We found that A, AB, and B blood types were associated with testing positive for COVID-19 compared with O blood type with the highest risk for the A blood group. We did not observe any genome-wide significant associations for COVID-19 severity outcomes among those testing positive. Our study replicates prior GWAS findings associated with testing positive for COVID-19 among mostly White samples and extends findings at three loci to Black and Hispanic individuals. We also report a new locus among Hispanics requiring further investigation. These findings may aid in the identification of novel therapeutic agents to decrease the morbidity and mortality of COVID-19 across all major ancestral populations.","journal":"Frontiers in Genetics","year":2022,"id":258329,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":280945,"name":"Catherine Tcheandjieu","orcid":"0000-0001-9559-4339","position":1,"is_corresponding":false},{"id":475559,"name":"John E. McGeary","orcid":"0000-0003-4025-9511","position":2,"is_corresponding":false},{"id":523487,"name":"Daniel Posner","orcid":"0000-0002-3056-6924","position":3,"is_corresponding":false},{"id":480530,"name":"Yuk‐Lam Ho","orcid":"0000-0003-3305-3830","position":4,"is_corresponding":false},{"id":329777,"name":"Jin Zhou","orcid":"0000-0001-7983-0274","position":5,"is_corresponding":false},{"id":11226,"name":"Austin T. Hilliard","orcid":"0000-0002-1289-4377","position":6,"is_corresponding":false},{"id":266924,"name":"Jacob Joseph","orcid":"0000-0002-7279-4896","position":7,"is_corresponding":false},{"id":27389,"name":"Christopher J. O’Donnell","orcid":"0000-0002-2667-8624","position":8,"is_corresponding":false},{"id":808836,"name":"Jimmy T. Efird","orcid":"0000-0002-4890-5111","position":9,"is_corresponding":false},{"id":21864,"name":"Dana C. Crawford","orcid":"0000-0002-6437-6248","position":10,"is_corresponding":false},{"id":440205,"name":"Wen‐Chih Wu","orcid":"0000-0002-2834-2024","position":11,"is_corresponding":false},{"id":350031,"name":"Mehrdad Arjomandi","orcid":"0000-0002-0116-9217","position":12,"is_corresponding":false},{"id":807225,"name":"VA Million Veteran Program COVID-19 Science Initiative","orcid":null,"position":13,"is_corresponding":false},{"id":22017,"name":"Yan V. Sun","orcid":"0000-0002-2838-1824","position":14,"is_corresponding":false},{"id":7147,"name":"Themistocles L. Assimes","orcid":"0000-0003-2349-0009","position":15,"is_corresponding":false},{"id":108708,"name":"Jennifer E. Huffman","orcid":"0000-0002-9672-2491","position":16,"is_corresponding":false},{"id":24655,"name":"Gina M. Peloso","orcid":"0000-0002-5355-8636","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:38.634785Z","pmid":"35222515","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}