{"doi":"10.3389/fgene.2021.774922","title":"Current HLA Investigations on SARS-CoV-2 and Perspectives","abstract":"The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics’ interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.","journal":"Frontiers in Genetics","year":2021,"id":179905,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":661658,"name":"Erick C. Castelli","orcid":"0000-0003-2142-7196","position":1,"is_corresponding":false},{"id":671952,"name":"Steven J. Mack","orcid":"0000-0001-9820-9547","position":2,"is_corresponding":false},{"id":420671,"name":"Jill A. Hollenbach","orcid":"0000-0001-6572-7962","position":3,"is_corresponding":false},{"id":397478,"name":"Pierre‐Antoine Gourraud","orcid":"0000-0003-1131-9554","position":4,"is_corresponding":false},{"id":397471,"name":"Nicolas Vince","orcid":"0000-0002-3767-6210","position":5,"is_corresponding":false},{"id":32970,"name":"Sophie Limou","orcid":"0000-0002-7702-8234","position":6,"is_corresponding":false},{"id":397473,"name":"Venceslas Douillard","orcid":"0000-0002-6762-4083","position":0,"is_corresponding":true}],"reference_count":92,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:47:53.089578Z","pmid":"34912378","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}