{"doi":"10.3389/fepid.2024.1342917","title":"Different clinical characteristics and outcomes of adult hospitalized SARS-CoV-2 pneumonia patients complicated by cardiovascular events during the first, delta and omicron waves of COVID-19","abstract":"Background: The effects of SARS-CoV-2 have varied between significant waves of hospitalization. Research question: Are cardiovascular complications different among the first, delta and omicron waves of hospitalized COVID-19 pneumonia patients? Study design and methods: (January 2022-July 2022). Patients were stratified by wave and occurrence of cardiovascular events. Results: Among all hospitalized patients with cardiovascular events, patients in the omicron wave were younger (62.4 ± 14 years) than patients in the first wave (67.4 ± 7.8 years) and the delta wave (66.9 ± 12.6 years) and had a higher proportion of non-Hispanic White people than in the first wave (78.6% vs. 61.7%). For COVID-19 patients who suffered from cardiovascular events, the omicron wave patients had significantly higher neutrophil/lymphocyte ratio, white blood cell and platelet counts when compared to the first wave. Omicron wave patients had significantly lower albumin and B-type natriuretic peptide levels (only 5.8% of the first wave and 14.6% of the delta wave) when compared to either the first wave or delta wave patients. In COVID-19 patients who suffered cardiovascular events during hospitalization, mortality rate in the omicron wave (26.8%) was significantly lower than the first wave (48.3%), time to mortality for non-survivors of COVID-19 patients who suffered cardiovascular events was significantly longer in the omicron wave (median 16 days) than in the first wave (median 10 days). Conclusions: Younger and white patients were affected with cardiovascular complications more often by the omicron variant. Despite higher neutrophil/lymphocyte ratio and WBC counts, the omicron patients with cardiovascular events showed lower heart injuries, lower mortality and longer time to mortality for non-survivors when compared to the first and delta waves.","journal":"Frontiers in Epidemiology","year":2024,"id":475125,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7256,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":740872,"name":"Harideep Samanapally","orcid":"0000-0002-1319-7549","position":1,"is_corresponding":false},{"id":584555,"name":"T’shura Ali","orcid":"0000-0002-7655-4283","position":2,"is_corresponding":false},{"id":500748,"name":"Qian Xu","orcid":"0000-0003-3223-7793","position":3,"is_corresponding":false},{"id":1296890,"name":"Yuchen Han","orcid":"0000-0002-2548-5492","position":4,"is_corresponding":false},{"id":744590,"name":"Vidyulata Salunkhe","orcid":"0000-0003-2568-3082","position":5,"is_corresponding":false},{"id":943462,"name":"Fnu Deepti","orcid":"0000-0002-2980-5393","position":6,"is_corresponding":false},{"id":1296891,"name":"Trevor McGuffin","orcid":"0000-0003-4356-1679","position":7,"is_corresponding":false},{"id":1297368,"name":"Emma C. Huang","orcid":null,"position":8,"is_corresponding":false},{"id":442349,"name":"Stephen Furmanek","orcid":"0000-0001-9112-2860","position":9,"is_corresponding":false},{"id":943463,"name":"Alex Glynn","orcid":"0000-0002-3027-7276","position":10,"is_corresponding":false},{"id":527187,"name":"Julio A. Ramírez","orcid":"0000-0001-7801-5374","position":11,"is_corresponding":false},{"id":1311969,"name":"Christopher M. Jones","orcid":"0000-0003-1478-489X","position":12,"is_corresponding":false},{"id":1312292,"name":"Ramesh Mariyappa","orcid":null,"position":13,"is_corresponding":false},{"id":1312293,"name":"Ryan J. Hogue","orcid":null,"position":14,"is_corresponding":false},{"id":1312294,"name":"Alexander M. Williams","orcid":null,"position":15,"is_corresponding":false},{"id":1297369,"name":"Justin J. Huang","orcid":null,"position":16,"is_corresponding":false},{"id":716855,"name":"Forest W. Arnold","orcid":"0000-0002-9279-2046","position":18,"is_corresponding":false},{"id":631624,"name":"Sean P. Clifford","orcid":null,"position":19,"is_corresponding":false},{"id":744593,"name":"Siddharth Pahwa","orcid":"0000-0001-9190-984X","position":20,"is_corresponding":false},{"id":293992,"name":"Maiying Kong","orcid":"0000-0002-7313-9084","position":21,"is_corresponding":false},{"id":630855,"name":"Jiapeng Huang","orcid":"0000-0002-4794-8400","position":22,"is_corresponding":false},{"id":1296893,"name":"Lynn Roser","orcid":"0000-0001-6636-2520","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:06:16.992586Z","pmid":"38699405","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}