{"doi":"10.3389/fendo.2022.906340","title":"Editorial: The Legacy of Dr. Leonard D. Kohn to Thyroid Pathophysiology","abstract":"following ER stress that can lead to a loss of thyroid function.Lee et al. investigate the role of the primary cilium of thyrocytes in thyroglobulin (Tg) endocytosis 66 using \"in vivo\" murine models. They demonstrated that the Lrp2/megalin complex, involved in Tg 67 uptake, is localized in the primary cilium of thyroid follicular cells. It is interesting to note that the 68 interaction between Tg and thyroid cell membrane was an old interest of Len (5), this interest was 69 subsequently directed to the role of Tg in the regulation of thyroid growth and function (6, 7). 70 Three original research articles, from Korean researchers, deal with some clinical features of thyroid 71 cancer. 72The study by Park J et al. evaluate the incidence of childhood thyroid cancer in Korea between 1999 73 and 2017. They found that, unlike adults, the incidence of thyroid cancer in children continues to 74 increase. The authors also collected epidemiological data on radiation exposure, iodine intake, 75 prevalence of obesity, and behavior habits that provide some explanation for this finding.","journal":"Frontiers in Endocrinology","year":2022,"id":309886,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9621,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1005064,"name":"Hiroki Shimura","orcid":"0000-0002-9770-2943","position":1,"is_corresponding":false},{"id":1005065,"name":"Jae Hoon Chung","orcid":"0000-0002-9563-5046","position":2,"is_corresponding":false},{"id":1005066,"name":"Giorgio Napolitano","orcid":"0000-0002-7698-7687","position":3,"is_corresponding":false},{"id":781870,"name":"Cesidio Giuliani","orcid":"0000-0002-6915-5057","position":0,"is_corresponding":true}],"reference_count":8,"raw_metadata":null,"created_at":"2026-07-19T00:33:15.860993Z","pmid":"35757398","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}