{"doi":"10.3389/fendo.2022.891379","title":"Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass","abstract":"Objective: Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes to weight reduction, and glycemic and lipid control after Roux-en-Y gastric bypass (RYGB). Design: mice were fed high fat diet for 12 weeks before surgery, and continued to be on the same diet for 3 weeks after surgery. Body weight, food intake, glycemic and lipid metabolism were analyzed before and after surgery. Results: Gastric and circulating ghrelin was significantly increased in mice with RYGB surgery. Hypoghrelinemia elicited by deletion of TSC1 to activate mTOR signaling in gastric X/A like cells demonstrated no effect on weight reduction, glycemic and lipid control induced by Roux-en-Y gastric bypass surgery. Conclusion: Lower ghrelin levels does not impact the metabolic benefit induced by Roux-en-Y gastric bypass.","journal":"Frontiers in Endocrinology","year":2022,"id":294665,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9625,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":980372,"name":"Ruili Yu","orcid":null,"position":1,"is_corresponding":false},{"id":980001,"name":"Rui He","orcid":"0000-0002-3059-1281","position":2,"is_corresponding":false},{"id":347955,"name":"Lijun Sun","orcid":"0000-0002-1579-2253","position":3,"is_corresponding":false},{"id":980002,"name":"Chao Luo","orcid":"0000-0001-6112-1592","position":4,"is_corresponding":false},{"id":94192,"name":"Feng Lu","orcid":"0000-0003-3933-8490","position":5,"is_corresponding":false},{"id":980003,"name":"Hong Chen","orcid":"0000-0002-4152-624X","position":6,"is_corresponding":false},{"id":454332,"name":"Yue Yin","orcid":"0000-0001-6497-5382","position":7,"is_corresponding":false},{"id":490273,"name":"Weizhen Zhang","orcid":"0000-0001-8791-2798","position":8,"is_corresponding":false},{"id":497233,"name":"Yuan Liang","orcid":"0000-0003-4551-610X","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T00:31:01.450041Z","pmid":"36082078","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}