{"doi":"10.3389/fendo.2022.837705","title":"Editorial: Molecular Mechanisms in Cancer Endocrinology With Clinical Implications","abstract":"Endocrine neoplasms are unique tumors with variable malignant potential and diverse clinical characteristics. In addition to the tumor progression and metastasis seen in other neoplasms, patients with endocrine tumors often present with syndromes related to excessive production of metabolically-active hormones, cytokines, and/or various peptides. The presentations range from asymptomatic patients with abnormal routine laboratory finding such as that seen in primary hyperparathyroidism, or incidentally-discovered adrenal or pancreatic lesions, to catastrophic conditions seen in patients with pheochromocytoma or carcinoid crises. Similarly, tumor size can range from occult or microscopic disease such as in ectopic ACTH-producing tumors or insulinoma to large tumor burden in patients with metastatic neuroendocrine tumors or adrenocortical cancer. The improved understanding of tumor biology and underlying molecular alterations associated with tumor initiation and progression in endocrine cancers has increasingly been translated into clinical use resulting in more accurate diagnostic tests, risk-stratification, novel and sensitive theranostic imaging studies, and targeted systemic therapy in several endocrine cancers. In this Research Topic, the authors discussed the key molecular alterations that have important clinical implications in thyroid cancer, familial parathyroid tumor syndromes, functioning adrenocortical neoplasms, pheochromocytoma, and paraganglioma, small bowel, and pancreatic neuroendocrine tumors.","journal":"Frontiers in Endocrinology","year":2022,"id":306139,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9647,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":238362,"name":"Naris Nilubol","orcid":"0000-0002-7348-7804","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:32:44.983506Z","pmid":"35295984","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}