{"doi":"10.3389/fendo.2022.1010806","title":"Differential effects of Akkermansia-enriched fecal microbiota transplant on energy balance in female mice on high-fat diet","abstract":"Estrogens protect against weight gain and metabolic disruption in women and female rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic disorders. Furthermore, estrogen-mediated protection against diet-induced metabolic disruption is associated with modifications in gut microbiota. In this study, we tested if estradiol (E2)-mediated protection against obesity and metabolic disorders in female mice is dependent on gut microbiota. Specifically, we tested if fecal microbiota transplantation (FMT) from E2-treated lean female mice, supplemented with or without Akkermansia muciniphila , prevented high fat diet (HFD)-induced body weight gain, fat mass gain, and hyperglycemia in female recipients. FMT from, and cohousing with, E2-treated lean donors was not sufficient to transfer the metabolic benefits to the E2-deficient female recipients. Moreover, FMT from lean donors supplemented with A. muciniphila exacerbated HFD-induced hyperglycemia in E2-deficient recipients, suggesting its detrimental effect on the metabolic health of E2-deficient female rodents fed a HFD. Given that A. muciniphila attenuates HFD-induced metabolic insults in males, the present findings suggest a sex difference in the impact of this microbe on metabolic health.","journal":"Frontiers in Endocrinology","year":2022,"id":259201,"datarank":0.4335557636844247,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.0,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":294295,"name":"Randall H. Friedline","orcid":"0000-0003-0894-448X","position":1,"is_corresponding":false},{"id":19838,"name":"Doyle V. Ward","orcid":"0000-0002-4952-824X","position":2,"is_corresponding":false},{"id":641109,"name":"Madeline Graham","orcid":"0000-0003-1231-0578","position":3,"is_corresponding":false},{"id":640709,"name":"LAUREN A. TAUER","orcid":"0000-0002-2315-1050","position":4,"is_corresponding":false},{"id":911905,"name":"Doris Zheng","orcid":null,"position":5,"is_corresponding":false},{"id":640710,"name":"Xiaodi Hu","orcid":"0000-0001-9704-2474","position":6,"is_corresponding":false},{"id":71942,"name":"Willem M. de Vos","orcid":"0000-0002-0273-3166","position":7,"is_corresponding":false},{"id":625978,"name":"Beth A. McCormick","orcid":"0000-0001-5992-2673","position":8,"is_corresponding":false},{"id":245309,"name":"Jason K. Kim","orcid":"0000-0002-7185-042X","position":9,"is_corresponding":false},{"id":249390,"name":"Marc J. Tetel","orcid":"0000-0002-9843-4071","position":10,"is_corresponding":false},{"id":249388,"name":"Kalpana D. Acharya","orcid":"0000-0001-6263-4357","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:25:47.305414Z","pmid":"36387852","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}