{"doi":"10.3389/fendo.2020.00578","title":"Post Meal Exercise May Lead to Transient Hypoglycemia Irrespective of Glycemic Status in Humans","abstract":"During exercise, there is coordination between various hormonal systems to ensure glucoregulation. This study examined if hypoglycemia occurs during moderate-intensity exercise in non-obese and obese individuals with and without type 2 diabetes (T2D). Eighteen non-obese, 18 obese and 10 obese with T2D were recruited. Each subject completed 2 study days that included a standard meal at 1800-h followed by rest (NOEX) or exercise (PMEX; 45 min at 55% of VO2max 2-h post meal). Glucose, insulin and glucagon concentrations were measured throughout this 5.5-h period. Subjects with T2D had elevated glucose responses to the meal on both study days, compared to non-obese and obese subjects (P<0.05). During exercise on PMEX, subjects with T2D had a greater drop in glucose concentration (-98.4±13.3 mg/dL) compared to obese (-44.8±7.1 mg/dL) and non-obese (-39.3±6.1 mg/dL; P<0.01) subjects. Glucose levels decreased more so in females than males in both conditions (P<0.01). Nadir glucose levels <70 mg/dL were observed in 33 subjects during NOEX and 39 subjects during PMEX. Obese males had a larger exercise-induced insulin drop than obese females (P=0.01). During PMEX, peak glucagon concentrations were elevated compared to NOEX (P<0.001). Male participants with T2D had an increased glucagon response during NOEX and PMEX compared to females (P<0.01). In conclusion, in sedentary individuals there is a dramatic drop in glucose levels during moderate-intensity exercise, despite appropriate insulin concentrations prior to exercise, and glucagon levels rising. Moderate-intensity exercise can lower exercise glucose concentrations below 60 mg/dL, and many individuals will be asymptomatic.","journal":"Frontiers in Endocrinology","year":2020,"id":90263,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9703,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":455859,"name":"Ryan Pettit‐Mee","orcid":null,"position":1,"is_corresponding":false},{"id":455860,"name":"Sean T. Ready","orcid":null,"position":2,"is_corresponding":false},{"id":369736,"name":"Ying Liu","orcid":"0000-0001-7710-0809","position":3,"is_corresponding":false},{"id":402586,"name":"Guido Lastra","orcid":"0000-0001-9205-1021","position":4,"is_corresponding":false},{"id":455094,"name":"Anand Chockalingam","orcid":"0000-0002-4502-1759","position":5,"is_corresponding":false},{"id":251152,"name":"Nathan C. Winn","orcid":"0000-0002-5276-0592","position":6,"is_corresponding":false},{"id":455861,"name":"Laura Clart","orcid":null,"position":7,"is_corresponding":false},{"id":455095,"name":"Jill A. Kanaley","orcid":"0000-0002-6558-4401","position":8,"is_corresponding":false},{"id":455858,"name":"Jay W. Porter","orcid":null,"position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T22:02:48.683291Z","pmid":"32982972","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}