{"doi":"10.3389/fendo.2020.00327","title":"Enhanced Myeloid Leukocytes in Obese Children and Adolescents at Risk for Metabolic Impairment","abstract":"Objective: We aimed to examine if myeloid leukocyte profiles are associated with metabolic impairment in children and adolescents with obesity, and if sex, age, or race influence this relationship. Methods: 282 children ages 8-17 were evaluated. Predictor measures were absolute neutrophil counts (ANC), absolute monocyte count, monocyte subtypes and C reactive protein (CRP). Outcome variables were waist circumference, fasting glucose and insulin, HOMA-IR, HbA1c (%) and lipid profiles. Pearson correlation coefficients were used to determine associations between predictor and outcome variables. Wilcoxon two-sample tests were used to evaluate differences by sex. Results: CRP (p<0.0001), ANC (p<0.0018), and classical monocytes (p=0.05) were significantly higher in children with obesity. CRP, ANC and classical monocytes showed positive correlations with waist circumference, insulin, HOMA-IR and triglycerides. CRP was positively associated with ANC overall (p=0.05). ANC demonstrated positive correlation with monocytes (p<0.001). The associations between predictor and outcome variables were influenced by sex, race and age. Conclusions: CRP and myeloid leukocyte populations, specifically classical monocytes and neutrophils associate with both body composition and metabolic parameters in children with obesity suggesting that these cells may play a critical role in metabolic impairment. Race, gender and age interactions between monocytes and metabolic parameters were significant.","journal":"Frontiers in Endocrinology","year":2020,"id":78705,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":410498,"name":"Ayse Bulan","orcid":null,"position":1,"is_corresponding":false},{"id":410499,"name":"Emily Hirschfeld","orcid":null,"position":2,"is_corresponding":false},{"id":410500,"name":"Phillip Wachowiak","orcid":null,"position":3,"is_corresponding":false},{"id":410501,"name":"Simin Abrishami","orcid":null,"position":4,"is_corresponding":false},{"id":176127,"name":"Cameron Griffin","orcid":null,"position":5,"is_corresponding":false},{"id":409335,"name":"Julie Sturza","orcid":"0009-0006-1486-1890","position":6,"is_corresponding":false},{"id":410502,"name":"Abigail Tzau","orcid":null,"position":7,"is_corresponding":false},{"id":410503,"name":"Taryn Hayes","orcid":null,"position":8,"is_corresponding":false},{"id":409336,"name":"Susan J. Woolford","orcid":"0000-0003-4431-0652","position":9,"is_corresponding":false},{"id":277960,"name":"Carey N. Lumeng","orcid":"0000-0003-0303-6204","position":10,"is_corresponding":false},{"id":341900,"name":"Joyce M. Lee","orcid":"0000-0002-8147-5168","position":11,"is_corresponding":false},{"id":409337,"name":"Kanakadurga Singer","orcid":"0000-0001-8278-3800","position":12,"is_corresponding":false},{"id":410497,"name":"Cecilia Gállego-Suárez","orcid":null,"position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T21:50:09.793321Z","pmid":"32528415","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}