{"doi":"10.3389/fendo.2018.00266","title":"Food-Anticipatory Behavior in Neonatal Rabbits and Rodents: An Update on the Role of Clock Genes","abstract":null,"journal":"Frontiers in Endocrinology","year":2018,"id":651045,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1697805,"name":"Jorge Mendoza","orcid":null,"position":1,"is_corresponding":false},{"id":1697804,"name":"Mario Caba","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Food-Anticipatory Behavior in Neonatal Rabbits and Rodents: An Update on the Role of Clock Genes","abstract":"In mammals, the suprachiasmatic nucleus (SCN), the master circadian clock, is mainly synchronized to the environmental light/dark cycle. SCN oscillations are maintained by a molecular clockwork in which certain genes, Period 1-2, Cry1-2, Bmal1, and Clock, are rhythmically expressed. Disruption of these genes leads to a malfunctioning clockwork and behavioral and physiological rhythms are altered. In addition to synchronization of circadian rhythms by light, when subjects are exposed to food for a few hours daily, behavioral and physiological rhythms are entrained to anticipate mealtime, even in the absence of the SCN. The presence of anticipatory rhythms synchronized by food suggests the existence of an SCN-independent circadian pacemaker that might be dependent on clock genes. Interestingly, rabbit pups, unable to perceive light, suckle milk once a day, which entrains behavioral rhythms to anticipate nursing time. Mutations of clock genes, singly or in combination, affect diverse rhythms in brain activity and physiological processes, but anticipatory behavior and physiology to feeding time remains attenuated or unaffected. It had been suggested that compensatory upregulation of paralogs or subtypes genes, or even non-transcriptional mechanisms, are able to maintain circadian oscillations entrained to mealtime. In the present mini-review, we evaluate the current state of the role played by clock genes in meal anticipation and provide evidence for rabbit pups as a natural model of food-anticipatory circadian behavior.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29881373","pmcid":"PMC5976783","openalex_id":"https://openalex.org/W2799459738","authors":[],"funders":[{"funder_name":"Agence Nationale de la Recherche","grant_id":"ANR-14-CE13-0002-01","title":null},{"funder_name":"French National Research Agency (ANR)","grant_id":"ANR-14-CE13-0002","title":"Molecular and neural implications of the body clock in food addiction: illuminating the avenue against obesity"}],"total_grants":2,"fwci":0.3818,"citation_percentile":0.51173614,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2022,"count":4},{"year":2023,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00266/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fendo.2018.00266/pdf","host_type":"publisher"},{"url":"https://www.frontiersin.org/article/10.3389/fendo.2018.00266/full","host_type":"publisher"},{"url":"https://doi.org/10.3389/fendo.2018.00266","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29881373","host_type":"repository"},{"url":"https://hal.science/hal-02386646","host_type":"repository"},{"url":"https://doaj.org/article/78c110d3c539450097d7c46211543025","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5976783","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5976783","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5976783?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3389/fendo.2018.00266","host_type":""},{"url":"https://dx.doi.org/10.3389/fendo.2018.00266","host_type":""},{"url":"https://hal.science/hal-02386646v1","host_type":""},{"url":"https://hal.science/hal-02386646v1/document","host_type":""}],"fields_of_study":["Circadian rhythm and melatonin","Neuroendocrine regulation and behavior","Genetics, Aging, and Longevity in Model Organisms","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Suprachiasmatic nucleus","Clockwork","Circadian rhythm","CLOCK","Oscillating gene","Light effects on circadian rhythm","Biology","Circadian clock","Period (music)","Anticipation (artificial intelligence)","Bacterial circadian rhythms","Neuroscience","Rhythm","Chronobiology","Timeless","Endocrinology","Internal medicine","Medicine","Corticosterone","Circadian rhythms","Food Entrainment","Restricted Feeding","Clock Gene Mutant","Per1 Protein","RC648-665","Diseases of the endocrine glands. Clinical endocrinology","[SDV.BA.ZV] Life Sciences [q-bio]/Animal biology/Vertebrate Zoology","[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T06:32:49.134870Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}