{"doi":"10.3389/fendo.2016.00076","title":"MyomiRs as Markers of Insulin Resistance and Decreased Myogenesis in Skeletal Muscle of Diet-Induced Obese Mice","abstract":null,"journal":"Frontiers in Endocrinology","year":2016,"id":596608,"datarank":0.5709993734655481,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.0,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1308875,"name":"Mariana de Mendonça","orcid":"0000-0002-8848-6468","position":1,"is_corresponding":false},{"id":1528026,"name":"Amanda Roque Martins","orcid":null,"position":2,"is_corresponding":false},{"id":1528028,"name":"Ana Flávia Gindro","orcid":null,"position":3,"is_corresponding":false},{"id":1233504,"name":"Bruno Cogliati","orcid":"0000-0002-1388-7240","position":4,"is_corresponding":false},{"id":140816,"name":"Rui Curi","orcid":null,"position":5,"is_corresponding":false},{"id":409662,"name":"Alice Cristina Rodrigues","orcid":"0000-0002-9005-033X","position":6,"is_corresponding":false},{"id":1528024,"name":"Flávia de Toledo Frias","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"MyomiRs as Markers of Insulin Resistance and Decreased Myogenesis in Skeletal Muscle of Diet-Induced Obese Mice","abstract":"High-fat diet (HFD) feeding causes insulin resistance (IR) in skeletal muscle of mice, which affects skeletal muscle metabolism and function. The involvement of muscle-specific microRNAs in the evolution of skeletal muscle IR during 4, 8, and 12 weeks in HFD-induced obese mice was investigated. After 4 weeks in HFD, mice were obese, hyperglycemic, and hyperinsulinemic; however, their muscles were responsive to insulin stimuli. Expressions of MyomiRs (miR-1, miR-133a, and miR-206) measured in soleus muscles were not different from those found in control mice. After 8 weeks of HFD feeding, glucose uptake was lower in skeletal muscle from obese mice compared to control mice, and we observed a significant decrease in miR-1a in soleus muscle when compared to HFD for 4 weeks. miR-1a expression continued to decay within time. After 12 weeks of HFD, miR-133a expression was upregulated when compared to the control group. Expression of miR-1a was negatively correlated with glycemia and positively correlated with the constant rate of plasma glucose disappearance. Pioglitazone treatment could not reverse decreases of miR-1a levels induced by HFD. Targets of myomiRs involved in insulin-growth factor (IGF)-1 pathway, such as Igf-1, Irs-1, Rheb, and follistatin, were reduced after 12 weeks in HFD and Mtor increased, when compared to the control or HFD for 4 or 8 weeks. These findings suggest for the first time that miR-1 may be a marker of the development of IR in skeletal muscle. Evidence was also presented that impairment in myomiRs expression contributes to decreased myogenesis and skeletal muscle growth reported in diabetes.","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27445979","pmcid":"PMC4921801","openalex_id":"https://openalex.org/W2463478234","authors":[],"funders":[{"funder_name":"Fundação de Amparo à Pesquisa do Estado de São Paulo","grant_id":"2011/05876-6","title":null},{"funder_name":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","grant_id":"471085/2013-8","title":null}],"total_grants":2,"fwci":2.084,"citation_percentile":0.86998489,"influential_citations":0,"citation_trend":[{"year":2016,"count":2},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":9},{"year":2022,"count":4},{"year":2023,"count":5},{"year":2024,"count":4},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.frontiersin.org/articles/10.3389/fendo.2016.00076/pdf","host_type":"journal"},{"url":"https://www.frontiersin.org/articles/10.3389/fendo.2016.00076/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3389/fendo.2016.00076","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27445979","host_type":"repository"},{"url":"http://dx.doi.org/10.3389/fendo.2016.00076","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4921801","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4921801","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4921801?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Muscle Physiology and Disorders","Adipose Tissue and Metabolism","MicroRNA in disease regulation"],"mesh_terms":[],"keywords":["Internal medicine","Endocrinology","Skeletal muscle","Insulin resistance","Soleus muscle","Myogenesis","Insulin","Medicine","Biology","IGF-1","High-fat diet","MicroRNA","Myomirs"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T10:45:30.805446Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}